| Sonstiges: |
- Nachgewiesen in: USPTO Patent Grants
- Sprachen: English
- Patent Number: 10859,574
- Publication Date: December 08, 2020
- Appl. No: 16/157193
- Application Filed: October 11, 2018
- Assignees: MeMed Diagnostics Ltd. (Tirat HaCarmel, IL)
- Claim: 1. A method of treating a bacterial infection in a domesticated animal comprising: a. receiving an identification that a domesticated animal showing symptoms of an infectious disease has a reduced level of TNF-related apoptosis-inducing ligand (TRAIL) in a blood sample of said domesticated animal compared to a domesticated animal who does not have an infectious disease, wherein said blood sample is selected from the group consisting of whole blood, serum, plasma and a blood fraction that comprises lymphocytes, monocytes and granulocytes, wherein said level of TRAIL is measured using an antibody which binds to said TRAIL; and b. treating the bacterial infection of the domesticated animal with an antibiotic.
- Claim: 2. The method of claim 1 , further comprising measuring the polypeptide concentration of: i. CRP and Interferon gamma-induced protein 10 (IP10); ii. CRP, SAA and IP10; iii. CRP, SAA, PCT and IP10; or iv. CRP, SAA, IP10 and IL1RA.
- Claim: 3. The method of claim 1 , wherein the expression level of said TRAIL is determined electrophoretically or immunochemically.
- Claim: 4. The method of claim 3 , wherein the immunochemical detection is by flow cytometry, radioimmunoassay, immunofluorescence assay or by an enzyme-linked immunosorbent assay.
- Claim: 5. The method of claim 1 , wherein the level of said TRAIL is measured within about 24 hours after the sample is obtained.
- Claim: 6. The method of claim 1 , wherein the sample was stored at 12° C. or lower.
- Claim: 7. The method of claim 1 , further comprising measuring the polypeptide concentration of CRP.
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- Primary Examiner: Devi, Sarvamangala
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