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- Nachgewiesen in: USPTO Patent Grants
- Sprachen: English
- Patent Number: 6,890,529
- Publication Date: May 10, 2005
- Appl. No: 10/111914
- Application Filed: October 30, 2000
- Assignees: Valio LTD (Helsinki, FI)
- Claim: 1. A biologically pure culture of Lactobacillus helveticus LBK-16H, DSM 13137.
- Claim: 2. A bacterial preparation comprising a biologically pure culture of Lactobacillus helveticus LBK-16H, DSM 13137.
- Claim: 3. A bacterial preparation as claimed in claim 2 , further comprised of other microorganisms.
- Claim: 4. A bacterial preparation as claimed in claim 2 , wherein the preparation is in the form of lyophilized powder or a capsule.
- Claim: 5. A method of manufacturing an edible or natural product comprising cultivating the biologically pure culture of Lactobacillus helveticus LBK-16H, DSM 13137 according to claim 1 .
- Claim: 6. A method of manufacturing an edible or natural product as claimed in claim 5 , wherein the product is selected from the group consisting of a milk product and a beverage.
- Claim: 7. An edible product comprising the pure culture according to claim 1 , or the bacterial preparation according to claim 2 .
- Claim: 8. An edible product as claimed in claim 7 , wherein the edible product is a milk product.
- Claim: 9. An edible product as claimed in claim 7 , wherein the edible product is a beverage.
- Claim: 10. A method of promoting health comprising administering to a subject in need thereof an effective amount of a biologically pure culture of Lactobacillus helveticus LBK-16H, DSM 13137 as an edible product or a pharmaceutical.
- Claim: 11. A method of promoting health as claimed in claim 10 , wherein the subject has hypertension.
- Claim: 12. An antihypertensive product comprising a biologically pure culture of Lactobacillus helveticus LBK-16H, DSM 13137.
- Claim: 13. An antihypertensive product as claimed in claim 12 , wherein the antihypertensive product further comprises antihypertensive di- and tri-peptides.
- Claim: 14. An antihypertensive product as claimed in claim 12 , wherein the antihypertensive product further comprises at least one tripeptide selected from the group consisting of Ile-Pro-Pro and Val-Pro-Pro.
- Claim: 15. An edible product as claimed in claim 9 , wherein the beverage is selected from the group consisting of whey beverage, fruit beverage and beer.
- Current U.S. Class: 424/9/345
- Patent References Cited: 5449661 September 1995 Nakamura et al. ; 5541111 July 1996 Yamamoto et al. ; 5695796 December 1997 Yamamoto et al. ; 5766940 June 1998 Yamamoto et al. ; 5854029 December 1998 Yamamoto ; 6399140 June 2002 Allen et al. ; 6534304 March 2003 Yamamoto et al. ; 0 737 690 October 1996 ; 0 821 968 July 1999 ; 1016709 July 2000 ; 2 294 191 April 1996 ; 9916862 April 1999 ; WO 9940798 August 1999 ; WO 200132905 May 2001
- Other References: Catalog of Bacteria and Bacteriophages, 1989, American Type Cultur Collection, 17 th Edition, pp. 177, and 402. cited by other ; WPI, Derwent, accession No. 1994-268691, Calpis Shokuhin Kogyo KK: “Prepn. of peptide whichinhibits angiotensin conversion enzyme-by lactic acid bacterium culture of material with specified tri: peptide sequence”; & JP A 6197786, 19940719. cited by other ; WPI, Derwent, accession No. 1986-110323, Calpis Shokuhin Kogyo KK: “Drug for prophylaxis of hypotension—contains high mol. substance obtd. by removing cell and casein from fermented milk”, & JP 61053216, 19860317. cited by other ; PAJ/JPO, “Peptide, Angiotensinase Inhibiting Composition and Their Production”, Otsuka Shokuhin KK, &JP 9188694, 19970722. cited by other ; Anne Pihlanto-Leppala et al; “Angiotensin I Converting Enzyme Inhibitory Peptides Derived from Bovine Milk Proteins”, Int. Dairy Journal, vol 8, 1998, pp. 331. cited by other ; Yamamoto Naoyuki et al; “Antihypertensive Effect of the Peptides From Casein by an Extracellular Proteinase from Lactobacillus helveticus CP790”, J Dairy Sci., vol. 77, 1994, pp. 917-922. cited by other ; Korhonen et al, Induction of Nitric Oxide Synthesis by Probiotic Lactobacillus rhamnosus GG in J774 Macrophages and Human T84 Intestinal Epithelial Cells, Inflammation, vol. 25, No. 4, Aug. 2001. cited by other
- Assistant Examiner: Srivastava, Kailash C.
- Primary Examiner: Tate, Christophet R.
- Attorney, Agent or Firm: Nixon & Vanderhye
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