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The present invention relates to a method for increasing efficacy and/or possibility of therapeutic treatment of cancer, wherein any dys-regulatory mechanism, including inducing factor/s, of the production of immunoregulatory substances, including one or more cytokines, including IL-1β, IL-1Ra, IL-6, IL-10, IL-17, TNF-α, and others, is therapeutically controlled to minimise pathological production of such immunoregulatory substances, to enhance the therapeutic control of a malignant tumour in a subject suffering from a cancer, a method for analysing dys-regulatory mechanism controlling substances, kit for such analysis, use of certain compounds for preparing pharmaceutical preparations, and pharmaceutical preparations.

Titel:	METHOD FOR DETERMINING IMMUNE SYSTEM AFFECTING COMPOUNDS
Autor/in / Beteiligte Person:	Hakansson, Leif ; Hakansson, Annika ; Clinchy, Birgitta
Link:	Diesen Eintrag von USPTO anschauen (Volltext)
Veröffentlichung:	2010
Medientyp:	Patent
Sonstiges:	Nachgewiesen in: USPTO Patent Applications Sprachen: English Document Number: 20100323370 Publication Date: December 23, 2010 Appl. No: 12/822013 Application Filed: June 23, 2010 Assignees: CANIMGUIDE THERAPEUTICS AB (Hollviken, SE) Claim: 1-78. (canceled) Claim: 79. A method for screening a cancer patient comprising: detecting the presence of an albumin or an immunoglobulin fragment in a biological sample obtained from said patient, wherein said fragment of albumin or immunoglobulin is capable of binding to immune cells and inducing production of IL-6, IL-10, TNF-α, or IL-1β; and determining the cancer prognosis of said patient. Claim: 80. The method of claim 79, wherein said cancer is a breast cancer, a pancreatic cancer, a colon cancer, a renal cancer, or a melanoma. Claim: 81. The method of claim 79, wherein said biological sample is a tumor tissue, a tumor extract, serum, blood, or urine. Claim: 82. The method of claim 80, wherein said biological sample is a tumor tissue, a tumor extract, serum, blood, or urine. Claim: 83. The method of claim 79, wherein the presence of an albumin fragment is detected in said biological sample. Claim: 84. The method of claim 80, wherein the presence of an albumin fragment is detected in said biological sample. Claim: 85. The method of claim 81, wherein the presence of an albumin fragment is detected in said biological sample. Claim: 86. The method of claim 82, wherein the presence of an albumin fragment is detected in said biological sample. Claim: 87. The method of claim 79, further comprising measuring the binding of said fragment to a tumor cell or an immune cell. Claim: 88. The method of claim 82, further comprising measuring the binding of said fragment to a tumor cell or an immune cell. Claim: 89. The method of claim 86, further comprising measuring the binding of said fragment to a tumor cell or an immune cell. Claim: 90. The method of claim 79, further comprising measuring the production of IL-6, IL-10, TNF-α, or IL-1β by an immune cell after contact with said fragment. Claim: 91. The method of claim 82, further comprising measuring the production of IL-6, IL-10, TNF-α, or IL-1β by an immune cell after contact with said fragment. Claim: 92. The method of claim 86, further comprising measuring the production of IL-6, IL-10, TNF-α, or IL-1β by an immune cell after contact with said fragment. Current U.S. Class: 435/723 Current International Class: 01; 01

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METHOD FOR DETERMINING IMMUNE SYSTEM AFFECTING COMPOUNDS