Vitamin D, vitamin D binding protein, and longitudinal outcomes in COPD.
In: PLoS ONE, Jg. 10 (2015), Heft 3, S. e0121622
Online
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Zugriff:
Associations between Vitamin D3 [25(OH)D], vitamin D binding protein (VDBP) and chronic obstructive pulmonary disease (COPD) are previously reported. We aimed to further investigate these associations on longitudinal outcomes.426 COPD patients from western Norway, GOLD stage II-IV, aged 40-76, were followed every six-month from 2006 through 2009 with spirometry, bioelectrical impedance measurements and registration of exacerbation frequency. Serum 25(OH)D and VDBP levels were determined at study-entry by high-performance liquid chromatography coupled with mass spectrometry and enzyme immunoassays respectively. Yearly change in lung function and body composition was assessed by generalized estimating equations (GEE), yearly exacerbation rate by negative binomial regression models, and 5 years all-cause mortality by Cox proportional-hazard regression.1/3 of the patients had vitamin D deficiency (
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Vitamin D, vitamin D binding protein, and longitudinal outcomes in COPD.
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Autor/in / Beteiligte Person: | Louise J P Persson ; Aanerud, Marianne ; Pieter S Hiemstra ; Annika E Michelsen ; Ueland, Thor ; Jon A Hardie ; Aukrust, Pål ; Per S Bakke ; Tomas M L Eagan |
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Zeitschrift: | PLoS ONE, Jg. 10 (2015), Heft 3, S. e0121622 |
Veröffentlichung: | Public Library of Science (PLoS), 2015 |
Medientyp: | academicJournal |
ISSN: | 1932-6203 (print) |
DOI: | 10.1371/journal.pone.0121622 |
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