A Likelihood Ratio Approach for Utilizing Case-Control Data in the Clinical Classification of Rare Sequence Variants : Application to BRCA1 and BRCA2

Zanti, Maria ; O'Mahony, Denise G. ; et al.

Uppsala universitet, Medicinsk epidemiologi ; Cyprus Inst Neurol & Genet, Biostat Unit, Nicosia, Cyprus. ; QIMR Berghofer Med Res Inst, Populat Hlth Program, Brisbane, Qld, Australia. ; Univ Utah, Huntsman Canc Inst, Canc Control & Populat Sci, Salt Lake City, UT USA. ; Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England. ; Univ Helsinki, Dept Clin Genet, Helsinki Univ Hosp, Helsinki, Finland. ; Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Fred A Litwin Ctr Canc Genet, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada. ; Univ Calif Irvine, Dept Med, Genet Epidemiol Res Inst, Irvine, CA 92717 USA. ; Queens Univ, Dept Publ Hlth Sci, Kingston, ON, Canada.;Queens Univ, Canc Res Inst, Kingston, ON, Canada. ; Lund Univ, Dept Clin Sci Lund, Oncol, Lund, Sweden. ; Univ Med Ctr Hamburg Eppendorf, Inst Med Biometry & Epidemiol, Hamburg, Germany. ; Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev, Denmark.;Copenhagen Univ Hosp, Dept Clin Biochem, Herlev & Gentofte Hosp, Herlev, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark. ; German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.;Natl Ctr Tumor Dis NCT, Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany. ; Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld, Australia. ; Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA.;Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA. ; German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany. ; Inst Curie, Serv Genet, Paris, France.;Paris Sci Lettres Res Univ, Paris, France. ; Xerencia Xest Integrada Vigo SERGAS, Oncol & Genet Unit, Inst Invest Sanitaria Galicia Sur IISGS, Vigo, Spain. ; German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Univ Med Ctr Hamburg Eppendorf, Univ Canc Ctr Hamburg UCCH, Canc Epidemiol Grp, Hamburg, Germany. ; Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. ; Fox Chase Canc Ctr, Dept Clin Genet, 7701 Burholme Ave, Philadelphia, PA 19111 USA. ; IRCCS San Raffaele Sci Inst, Ctr Omics Sci, Milan, Italy. ; Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands.;Leiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands. ; Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany. ; Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England. ; Univ Westminster, Sch Life Sci, London, England. ; Univ Southampton, Fac Med, Southampton, Hants, England. ; Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany.;Univ Leipzig, Life Leipzig Res Ctr Civilizat Dis, Leipzig, Germany. ; Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Div Evolut & Genom Sci,Sch Biol Sci, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, St Marys Hosp, Manchester Acad Hlth Sci Ctr, North West Genom Lab Hub,Manchester Ctr Genom Med, Manchester, Lancs, England. ; Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Dept Gynecol & Obstet, Comprehens Canc Ctr Erlangen EMN, Erlangen, Germany. ; Complejo Hosp Univ Santiago, SERGAS,Fdn Publ Galega Med Xen, Inst Invest Sanitaria Santiago de Compostela IDIS, Genom Med Grp,Int Canc Genet & Epidemiol Grp, Santiago De Compostela, Spain. ; NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Bethesda, MD 20892 USA. ; Hosp Clin San Carlos, Med Oncol Dept, Inst Invest Sanitaria San Carlos IdISSC, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain. ; UCL, MRC Clin Trials Unit, Inst Clin Trials & Methodol, London, England. ; Erasmus Univ, Dept Clin Genet, Med Ctr, Rotterdam, Netherlands. ; Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia. ; Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Fred A Litwin Ctr Canc Genet, Toronto, ON, Canada. ; McGill Univ, Dept Med, Montreal, PQ, Canada.;McGill Univ, Div Clin Epidemiol, Royal Victoria Hosp, Montreal, PQ, Canada. ; Maastricht Univ, Dept Clin Genet, Med Ctr, Maastricht, Netherlands. ; German Canc Res Ctr, Mol Epidemiol Grp, C080, Heidelberg, Germany.;Heidelberg Univ, Univ Womens Clin Heidelberg, Mol Biol Breast Canc, Heidelberg, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Diabet Res, Neuherberg, Germany. ; Univ Paris Saclay, UVSQ, INSERM, Gustave Roussy,CESP,Team Exposome & Heredit, Villejuif, France. ; Univ Cologne, Fac Med, Ctr Familial Breast & Ovarian Canc, Cologne, Germany.;Univ Cologne, Univ Hosp Cologne, Cologne, Germany.;Univ Cologne, Fac Med, Ctr Integrated Oncol CIO, Cologne, Germany. ; Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA USA. ; Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Soder Sjukhuset, Dept Oncol, Stockholm, Sweden. ; German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany. ; Univ Manchester, Manchester Acad Hlth Sci Ctr, Div Informat Imaging & Data Sci, Fac Biol Med & Hlth, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, Wythenshawe Hosp, Nightingale & Genesis Prevent Ctr, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, Manchester Acad HealthSci Ctr, NIHR Manchester Biomed Res Unit, Manchester, Lancs, England. ; Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands. ; Erasmus MC Canc Inst, Dept Med Oncol, Rotterdam, Netherlands. ; Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany.;Univ Tubingen, Tubingen, Germany. ; Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia. ; Dept Genet, F-76000 Rouen, France.;Normandy Univ, UNIROUEN, Inserm U1245, Rouen Univ Hosp,Normandy Ctr Genom & Personalized, Rouen, France. ; Inst Canc Res, Div Genet & Epidemiol, London, England. ; Univ Manchester, Div Canc Sci, Manchester, Lancs, England. ; Univ Sydney, Westmead Inst Med Res, Australian Breast Canc Tissue Bank, Sydney, NSW, Australia. ; MASA, Res Ctr Genet Engn & Biotechnol Georgi D Efremov, Skopje, North Macedonia. ; Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland.;Pomeranian Med Univ, Independent Lab Mol Biol & Genet Diagnost, Szczecin, Poland. ; Stanford Univ, Dept Epidemiol & Populat Hlth, Sch Med, Stanford, CA USA.;Stanford Univ, Sch Med, Dept Med, Stanford Canc Inst, Stanford, CA USA. ; German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany. ; NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. ; Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA. ; Oslo Univ Hosp, Dept Med Genet, Oslo, Norway.;Univ Oslo, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway. ; City Hope Natl Med Ctr, Dept Computat & Quantitat Med, Duarte, CA USA.;City Hope Natl Med Ctr, City Hope Comprehens Canc Ctr, Duarte, CA USA. ; Katholieke Univ Leuven, Dept Human Genet, Lab Translat Genet, Leuven, Belgium.;VIB, VIB Ctr Canc Biol, Leuven, Belgium. ; Hosp Civils Lyon, Genet & Canc Med Lab HCL CLB, Bron, France. ; Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden. ; Univ Eastern Finland, Translat Canc Res Area, Kuopio, Finland.;Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, Kuopio, Finland.;Kuopio Univ Hosp, Biobank Eastern Finland, Kuopio, Finland. ; Fdn IRCCS Ist Nazl Tumori Milano, Unit Med Genet, Dept Med Oncol & Hematol, Milan, Italy. ; Soder Sjukhuset, Dept Oncol, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden. ; Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA.;Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, La Jolla, CA 92093 USA. ; H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA. ; Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada.;BC Canc, Canc Control Res, Vancouver, BC, Canada. ; City Hope Natl Med Ctr, Dept Populat Sci, Beckman Res Inst, Duarte, CA USA. ; Univ Helsinki, Dept Obstet & Gynecol, Helsinki Univ Hosp, Helsinki, Finland. ; Mem Sloan Kettering Canc Ctr, Clin Genet Res Lab, Dept Canc Biol & Genet, 1275 York Ave, New York, NY 10021 USA.;Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA. ; Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.;Seoul Natl Univ, Coll Med, Integrated Major Innovat Med Sci, Seoul, South Korea.;Seoul Natl Univ, Canc Res Inst, Seoul, South Korea. ; Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia.;Peter MacCallum Canc Ctr, Parkville Familial Canc Ctr, Melbourne, Vic, Australia.;Royal Melbourne Hosp, Melbourne, Vic, Australia. ; AIRC Inst Mol Oncol, Genome Diagnost Program, IFOM ETS, Milan, Italy. ; London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London, England. ; Leuven Canc Inst, Dept Gen Med Oncol, Leuven, Belgium.;Leuven Canc Inst, Multidisciplinary Breast Ctr, Leuven, Belgium.;Univ Hosp Leuven, Leuven, Belgium. ; Fdn IRCCS Ist Nazl Tumori INT, Unit Mol Bases Genet Risk & Genet Testing, Dept Res, Milan, Italy. ; German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany.;Shaukat Khanum Mem Canc Hosp & Res Ctr SKMCH & RC, Dept Basic Sci, Lahore, Pakistan. ; Carmel Hosp, Clalit Natl Canc Control Ctr, Haifa, Israel.;Technion Fac Med, Haifa, Israel. ; Hosp Univ Puerta de Hierro, Med Oncol Dept, Madrid, Spain. ; Antoni van Leeuwenhoek Hosp, Dept Pathol, Netherlands Canc Inst, Amsterdam, Netherlands. ; Univ Hosp Larissa, Dept Oncol, Larisa, Greece. ; NIEHS, Epidemiol Branch, NIH, POB 12233, Res Triangle Pk, NC 27709 USA. ; Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands.;Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands.;Leiden Univ, Dept Clin Genet, Med Ctr, Leiden, Netherlands. ; Univ Cologne, Fac Med, Ctr Familial Breast & Ovarian Canc, Cologne, Germany.;Univ Cologne, Univ Hosp Cologne, Cologne, Germany.;Univ Cologne, Fac Med, Ctr Integrated Oncol CIO, Cologne, Germany.;Univ Cologne, Fac Med, Ctr Mol Med Cologne CMMC, Cologne, Germany. ; Vanderbilt Univ, Dept Med, Vanderbilt Ingram Canc Ctr, Vanderbilt Epidemiol Ctr,Sch Med,Div Epidemiol, Nashville, TN USA. ; Univ Laval, Ctr Hosp Univ Quebec, Res Ctr, Genom Ctr, Quebec City, PQ, Canada. ; Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia.;Univ Melbourne, Dept Clin Pathol, Melbourne, Vic, Australia. ; Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.;Univ Western Australia, Sch Populat & Global Hlth, Genet Epidemiol Grp, Perth, WA, Australia. ; Inst Curie, Serv Genet, Paris, France.;INSERM U830, Dept Tumour Biol, Paris, France.;Univ Paris 05, Paris, France. ; Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Weill Cornell Med, Dept Populat Hlth Sci, New York, NY USA. ; NIEHS, Epidemiol Branch, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.;NIEHS, Epigenet & Stem Cell Biol Lab, NIH, POB 12233, Res Triangle Pk, NC 27709 USA. ; Canc Res Malaysia, Breast Canc Res Programme, Subang Jaya, Selangor, Malaysia.;Univ Malaya, UM Canc Res Inst, Dept Surg, Fac Med, Kuala Lumpur, Malaysia. ; Amer Canc Soc, Dept Populat Sci, Atlanta, GA 30329 USA. ; Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA. ; Odense Univ Hosp, Dept Clin Genet, Odence C, Denmark. ; Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.;Univ North Carolina Chapel Hill, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA. ; Mayo Clin, Dept Quantitat Hlth Sci, Div Epidemiol, Rochester, MN USA. ; Ctr Invest Red Enfermedades Raras CIBERER, Madrid, Spain.;Fdn Publ Galega Med Xenom, Santiago De Compostela, Spain.;Complejo Hosp Univ Santiago, SERGAS, Inst Invest Sanitaria Santiago de Compostela IDIS, Santiago De Compostela, Spain. ; Leiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands. ; NIEHS, Biostat & Computat Biol Branch, NIH, POB 12233, Res Triangle Pk, NC 27709 USA. ; Karolinska Inst, Inst Environm Med, Stockholm, Sweden. ; Univ Utah, Sch Med, Dept Dermatol, Huntsman Canc Inst, Salt Lake City, UT USA. ; Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA. ; Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.;Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England. ; Cyprus Inst Neurol & Genet, Biostat Unit, Nicosia, Cyprus.;Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England., 2023

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A large number of variants identified through clinical genetic testing in disease susceptibility genes are of uncertain significance (VUS). Following the recommendations of the American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP), the frequency in case-control datasets (PS4 criterion) can inform their interpretation. We present a novel case-control likelihood ratio-based method that incorporates gene-specific age-related penetrance. We demonstrate the utility of this method in the analysis of simulated and real datasets. In the analysis of simulated data, the likelihood ratio method was more powerful compared to other methods. Likelihood ratios were calculated for a case-control dataset of BRCA1 and BRCA2 variants from the Breast Cancer Association Consortium (BCAC) and compared with logistic regression results. A larger number of variants reached evidence in favor of pathogenicity, and a substantial number of variants had evidence against pathogenicity-findings that would not have been reached using other case-control analysis methods. Our novel method provides greater power to classify rare variants compared with classical case-control methods. As an initiative from the ENIGMA Analytical Working Group, we provide user-friendly scripts and preformatted Excel calculators for implementation of the method for rare variants in BRCA1, BRCA2, and other high-risk genes with known penetrance.

Titel:	A Likelihood Ratio Approach for Utilizing Case-Control Data in the Clinical Classification of Rare Sequence Variants : Application to BRCA1 and BRCA2
Autor/in / Beteiligte Person:	Zanti, Maria ; O'Mahony, Denise G. ; Parsons, Michael T. ; Li, Hongyan ; Dennis, Joe ; Aittomakkiki, Kristiina ; Andrulis, Irene L. ; Anton-Culver, Hoda ; Aronson, Kristan J. ; Augustinsson, Annelie ; Becher, Heiko ; Bojesen, Stig E. ; Bolla, Manjeet K. ; Brenner, Hermann ; Brown, Melissa A. ; Buys, Saundra S. ; Canzian, Federico ; Caputo, Sandrine M. ; Castelao, Jose E. ; Chang-Claude, Jenny ; Czene, Kamila ; Daly, Mary B. ; De Nicolo, Arcangela ; Devilee, Peter ; Dork, Thilo ; Dunning, Alison M. ; Dwek, Miriam ; Eccles, Diana M. ; Engel, Christoph ; Evans, D. Gareth ; Fasching, Peter A. ; Gago-Dominguez, Manuela ; Garcia-Closas, Montserrat ; Garcia-Saenz, Jose A. ; Gentry-Maharaj, Aleksandra ; Geurts-Giele, Willemina R. R. ; Giles, Graham G. ; Glendon, Gord ; Goldberg, Mark S. ; Garcia, Encarna B. Gomez ; Guendert, Melanie ; Guenel, Pascal ; Hahnen, Eric ; Haiman, Christopher A. ; Hall, Per ; Hamann, Ute ; Harkness, Elaine F. ; Hogervorst, Frans B. L. ; Hollestelle, Antoinette ; Hoppe, Reiner ; Hopper, John L. ; Houdayer, Claude ; Houlston, Richard S. ; Howell, Anthony ; Investigators, Abctb ; Jakimovska, Milena ; Jakubowska, Anna ; Jernstrom, Helena ; John, Esther M. ; Kaaks, Rudolf ; Kitahara, Cari M. ; Koutros, Stella ; Kraft, Peter ; Kristensen, Vessela N. ; Lacey, James, V ; Lambrechts, Diether ; Leone, Melanie ; Lindblom, Annika ; Lush, Michael ; Mannermaa, Arto ; Manoochehri, Mehdi ; Manoukian, Siranoush ; Margolin, Sara ; Martinez, Maria Elena ; Menon, Usha ; Milne, Roger L. ; Monteiro, Alvaro N. ; Murphy, Rachel A. ; Neuhausen, Susan L. ; Nevanlinna, Heli ; Newman, William G. ; Offit, Kenneth ; Park, Sue K. ; James, Paul ; Peterlongo, Paolo ; Peto, Julian ; Plaseska-Karanfilska, Dijana ; Punie, Kevin ; Radice, Paolo ; Rashid, Muhammad U. ; Rennert, Gad ; Romero, Atocha ; Rosenberg, Efraim H. ; Saloustros, Emmanouil ; Sandler, Dale P. ; Schmidt, Marjanka K. ; Schmutzler, Rita K. ; Shu, Xiao-Ou ; Simard, Jacques ; Southey, Melissa C. ; Stone, Jennifer ; Stoppa-Lyonnet, Dominique ; Tamimi, Rulla M. ; Tapper, William J. ; Taylor, Jack A. ; Teo, Soo Hwang ; Teras, Lauren R. ; Terry, Mary Beth ; Thomassen, Mads ; Troester, Melissa A. ; Vachon, Celine M. ; Vega, Ana ; Vreeswijk, Maaike P. G. ; Wang, Qin ; Wappenschmidt, Barbara ; Weinberg, Clarice R. ; Wolk, Alicja ; Zheng, Wei ; Feng, Bingjian ; Couch, Fergus J. ; Spurdle, Amanda B. ; Easton, Douglas F. ; Goldgar, David E. ; Michailidou, Kyriaki
Link:	Volltext https://doi.org/10.1155/2023/9961341
Veröffentlichung:	Uppsala universitet, Medicinsk epidemiologi ; Cyprus Inst Neurol & Genet, Biostat Unit, Nicosia, Cyprus. ; QIMR Berghofer Med Res Inst, Populat Hlth Program, Brisbane, Qld, Australia. ; Univ Utah, Huntsman Canc Inst, Canc Control & Populat Sci, Salt Lake City, UT USA. ; Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England. ; Univ Helsinki, Dept Clin Genet, Helsinki Univ Hosp, Helsinki, Finland. ; Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Fred A Litwin Ctr Canc Genet, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada. ; Univ Calif Irvine, Dept Med, Genet Epidemiol Res Inst, Irvine, CA 92717 USA. ; Queens Univ, Dept Publ Hlth Sci, Kingston, ON, Canada.;Queens Univ, Canc Res Inst, Kingston, ON, Canada. ; Lund Univ, Dept Clin Sci Lund, Oncol, Lund, Sweden. ; Univ Med Ctr Hamburg Eppendorf, Inst Med Biometry & Epidemiol, Hamburg, Germany. ; Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev, Denmark.;Copenhagen Univ Hosp, Dept Clin Biochem, Herlev & Gentofte Hosp, Herlev, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark. ; German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.;Natl Ctr Tumor Dis NCT, Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany. ; Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld, Australia. ; Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA.;Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA. ; German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany. ; Inst Curie, Serv Genet, Paris, France.;Paris Sci Lettres Res Univ, Paris, France. ; Xerencia Xest Integrada Vigo SERGAS, Oncol & Genet Unit, Inst Invest Sanitaria Galicia Sur IISGS, Vigo, Spain. ; German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Univ Med Ctr Hamburg Eppendorf, Univ Canc Ctr Hamburg UCCH, Canc Epidemiol Grp, Hamburg, Germany. ; Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. ; Fox Chase Canc Ctr, Dept Clin Genet, 7701 Burholme Ave, Philadelphia, PA 19111 USA. ; IRCCS San Raffaele Sci Inst, Ctr Omics Sci, Milan, Italy. ; Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands.;Leiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands. ; Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany. ; Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England. ; Univ Westminster, Sch Life Sci, London, England. ; Univ Southampton, Fac Med, Southampton, Hants, England. ; Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany.;Univ Leipzig, Life Leipzig Res Ctr Civilizat Dis, Leipzig, Germany. ; Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Div Evolut & Genom Sci,Sch Biol Sci, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, St Marys Hosp, Manchester Acad Hlth Sci Ctr, North West Genom Lab Hub,Manchester Ctr Genom Med, Manchester, Lancs, England. ; Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Dept Gynecol & Obstet, Comprehens Canc Ctr Erlangen EMN, Erlangen, Germany. ; Complejo Hosp Univ Santiago, SERGAS,Fdn Publ Galega Med Xen, Inst Invest Sanitaria Santiago de Compostela IDIS, Genom Med Grp,Int Canc Genet & Epidemiol Grp, Santiago De Compostela, Spain. ; NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Bethesda, MD 20892 USA. ; Hosp Clin San Carlos, Med Oncol Dept, Inst Invest Sanitaria San Carlos IdISSC, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain. ; UCL, MRC Clin Trials Unit, Inst Clin Trials & Methodol, London, England. ; Erasmus Univ, Dept Clin Genet, Med Ctr, Rotterdam, Netherlands. ; Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia. ; Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Fred A Litwin Ctr Canc Genet, Toronto, ON, Canada. ; McGill Univ, Dept Med, Montreal, PQ, Canada.;McGill Univ, Div Clin Epidemiol, Royal Victoria Hosp, Montreal, PQ, Canada. ; Maastricht Univ, Dept Clin Genet, Med Ctr, Maastricht, Netherlands. ; German Canc Res Ctr, Mol Epidemiol Grp, C080, Heidelberg, Germany.;Heidelberg Univ, Univ Womens Clin Heidelberg, Mol Biol Breast Canc, Heidelberg, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Diabet Res, Neuherberg, Germany. ; Univ Paris Saclay, UVSQ, INSERM, Gustave Roussy,CESP,Team Exposome & Heredit, Villejuif, France. ; Univ Cologne, Fac Med, Ctr Familial Breast & Ovarian Canc, Cologne, Germany.;Univ Cologne, Univ Hosp Cologne, Cologne, Germany.;Univ Cologne, Fac Med, Ctr Integrated Oncol CIO, Cologne, Germany. ; Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA USA. ; Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Soder Sjukhuset, Dept Oncol, Stockholm, Sweden. ; German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany. ; Univ Manchester, Manchester Acad Hlth Sci Ctr, Div Informat Imaging & Data Sci, Fac Biol Med & Hlth, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, Wythenshawe Hosp, Nightingale & Genesis Prevent Ctr, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, Manchester Acad HealthSci Ctr, NIHR Manchester Biomed Res Unit, Manchester, Lancs, England. ; Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands. ; Erasmus MC Canc Inst, Dept Med Oncol, Rotterdam, Netherlands. ; Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany.;Univ Tubingen, Tubingen, Germany. ; Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia. ; Dept Genet, F-76000 Rouen, France.;Normandy Univ, UNIROUEN, Inserm U1245, Rouen Univ Hosp,Normandy Ctr Genom & Personalized, Rouen, France. ; Inst Canc Res, Div Genet & Epidemiol, London, England. ; Univ Manchester, Div Canc Sci, Manchester, Lancs, England. ; Univ Sydney, Westmead Inst Med Res, Australian Breast Canc Tissue Bank, Sydney, NSW, Australia. ; MASA, Res Ctr Genet Engn & Biotechnol Georgi D Efremov, Skopje, North Macedonia. ; Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland.;Pomeranian Med Univ, Independent Lab Mol Biol & Genet Diagnost, Szczecin, Poland. ; Stanford Univ, Dept Epidemiol & Populat Hlth, Sch Med, Stanford, CA USA.;Stanford Univ, Sch Med, Dept Med, Stanford Canc Inst, Stanford, CA USA. ; German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany. ; NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. ; Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA. ; Oslo Univ Hosp, Dept Med Genet, Oslo, Norway.;Univ Oslo, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway. ; City Hope Natl Med Ctr, Dept Computat & Quantitat Med, Duarte, CA USA.;City Hope Natl Med Ctr, City Hope Comprehens Canc Ctr, Duarte, CA USA. ; Katholieke Univ Leuven, Dept Human Genet, Lab Translat Genet, Leuven, Belgium.;VIB, VIB Ctr Canc Biol, Leuven, Belgium. ; Hosp Civils Lyon, Genet & Canc Med Lab HCL CLB, Bron, France. ; Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden. ; Univ Eastern Finland, Translat Canc Res Area, Kuopio, Finland.;Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, Kuopio, Finland.;Kuopio Univ Hosp, Biobank Eastern Finland, Kuopio, Finland. ; Fdn IRCCS Ist Nazl Tumori Milano, Unit Med Genet, Dept Med Oncol & Hematol, Milan, Italy. ; Soder Sjukhuset, Dept Oncol, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden. ; Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA.;Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, La Jolla, CA 92093 USA. ; H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA. ; Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada.;BC Canc, Canc Control Res, Vancouver, BC, Canada. ; City Hope Natl Med Ctr, Dept Populat Sci, Beckman Res Inst, Duarte, CA USA. ; Univ Helsinki, Dept Obstet & Gynecol, Helsinki Univ Hosp, Helsinki, Finland. ; Mem Sloan Kettering Canc Ctr, Clin Genet Res Lab, Dept Canc Biol & Genet, 1275 York Ave, New York, NY 10021 USA.;Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA. ; Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.;Seoul Natl Univ, Coll Med, Integrated Major Innovat Med Sci, Seoul, South Korea.;Seoul Natl Univ, Canc Res Inst, Seoul, South Korea. ; Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia.;Peter MacCallum Canc Ctr, Parkville Familial Canc Ctr, Melbourne, Vic, Australia.;Royal Melbourne Hosp, Melbourne, Vic, Australia. ; AIRC Inst Mol Oncol, Genome Diagnost Program, IFOM ETS, Milan, Italy. ; London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London, England. ; Leuven Canc Inst, Dept Gen Med Oncol, Leuven, Belgium.;Leuven Canc Inst, Multidisciplinary Breast Ctr, Leuven, Belgium.;Univ Hosp Leuven, Leuven, Belgium. ; Fdn IRCCS Ist Nazl Tumori INT, Unit Mol Bases Genet Risk & Genet Testing, Dept Res, Milan, Italy. ; German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany.;Shaukat Khanum Mem Canc Hosp & Res Ctr SKMCH & RC, Dept Basic Sci, Lahore, Pakistan. ; Carmel Hosp, Clalit Natl Canc Control Ctr, Haifa, Israel.;Technion Fac Med, Haifa, Israel. ; Hosp Univ Puerta de Hierro, Med Oncol Dept, Madrid, Spain. ; Antoni van Leeuwenhoek Hosp, Dept Pathol, Netherlands Canc Inst, Amsterdam, Netherlands. ; Univ Hosp Larissa, Dept Oncol, Larisa, Greece. ; NIEHS, Epidemiol Branch, NIH, POB 12233, Res Triangle Pk, NC 27709 USA. ; Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands.;Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands.;Leiden Univ, Dept Clin Genet, Med Ctr, Leiden, Netherlands. ; Univ Cologne, Fac Med, Ctr Familial Breast & Ovarian Canc, Cologne, Germany.;Univ Cologne, Univ Hosp Cologne, Cologne, Germany.;Univ Cologne, Fac Med, Ctr Integrated Oncol CIO, Cologne, Germany.;Univ Cologne, Fac Med, Ctr Mol Med Cologne CMMC, Cologne, Germany. ; Vanderbilt Univ, Dept Med, Vanderbilt Ingram Canc Ctr, Vanderbilt Epidemiol Ctr,Sch Med,Div Epidemiol, Nashville, TN USA. ; Univ Laval, Ctr Hosp Univ Quebec, Res Ctr, Genom Ctr, Quebec City, PQ, Canada. ; Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia.;Univ Melbourne, Dept Clin Pathol, Melbourne, Vic, Australia. ; Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.;Univ Western Australia, Sch Populat & Global Hlth, Genet Epidemiol Grp, Perth, WA, Australia. ; Inst Curie, Serv Genet, Paris, France.;INSERM U830, Dept Tumour Biol, Paris, France.;Univ Paris 05, Paris, France. ; Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Weill Cornell Med, Dept Populat Hlth Sci, New York, NY USA. ; NIEHS, Epidemiol Branch, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.;NIEHS, Epigenet & Stem Cell Biol Lab, NIH, POB 12233, Res Triangle Pk, NC 27709 USA. ; Canc Res Malaysia, Breast Canc Res Programme, Subang Jaya, Selangor, Malaysia.;Univ Malaya, UM Canc Res Inst, Dept Surg, Fac Med, Kuala Lumpur, Malaysia. ; Amer Canc Soc, Dept Populat Sci, Atlanta, GA 30329 USA. ; Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA. ; Odense Univ Hosp, Dept Clin Genet, Odence C, Denmark. ; Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.;Univ North Carolina Chapel Hill, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA. ; Mayo Clin, Dept Quantitat Hlth Sci, Div Epidemiol, Rochester, MN USA. ; Ctr Invest Red Enfermedades Raras CIBERER, Madrid, Spain.;Fdn Publ Galega Med Xenom, Santiago De Compostela, Spain.;Complejo Hosp Univ Santiago, SERGAS, Inst Invest Sanitaria Santiago de Compostela IDIS, Santiago De Compostela, Spain. ; Leiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands. ; NIEHS, Biostat & Computat Biol Branch, NIH, POB 12233, Res Triangle Pk, NC 27709 USA. ; Karolinska Inst, Inst Environm Med, Stockholm, Sweden. ; Univ Utah, Sch Med, Dept Dermatol, Huntsman Canc Inst, Salt Lake City, UT USA. ; Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA. ; Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.;Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England. ; Cyprus Inst Neurol & Genet, Biostat Unit, Nicosia, Cyprus.;Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England., 2023
Medientyp:	academicJournal
DOI:	10.1155/2023/9961341
Schlagwort:	Cancer and Oncology Cancer och onkologi Medical Genetics Medicinsk genetik
Sonstiges:	Nachgewiesen in: BASE Sprachen: English Collection: Uppsala University: Publications (DiVA) Document Type: article in journal/newspaper File Description: application/pdf Language: English Rights: info:eu-repo/semantics/openAccess

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