Genetic architectures of proximal and distal colorectal cancer are partly distinct

Umeå universitet, Onkologi ; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States ; Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, OH, Columbus, United States ; Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, CA, Los Angeles, United States; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States ; Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States ; Department of Preventive Medicine and Usc Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, CA, Los Angeles, United States ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, MI, Ann Arbor, United States ; Department of Medicine, University of North Carolina School of Medicine, NC, Chapel Hill, United States ; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom ; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States; Upmc Hillman Cancer Center, PA, Pittsburgh, United States ; Translational Genomics Research Institute-An Affiliate of City of Hope, AZ, Phoenix, United States ; Public Health Division of Gipuzkoa, Health Department of Basque Country, San Sebastian, Spain ; Department of Biostatistics, University of Washington, WA, Seattle, United States ; Laboratoire de Mathématiques Appliqueés MAP5 (UMR Cnrs 8145), Université Paris Descartes, Paris, France; Centre for Research in Epidemiology and Population Health (CESP), Institut Pour la Santé et la Recherche Médicale (INSERM) U1018, Université Paris-Saclay, Villejuif, France ; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom ; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States ; Department of Population and Quantitative Health Sciences, Case Western Reserve University, OH, Cleveland, United States ; Department of Internal Medicine, University of Utah Health, UT, Salt Lake City, United States ; Departments of Cancer Biology and Genetics and Internal Medicine, The Ohio State University, OH, Columbus, United States ; Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, Netherlands ; Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, l'Hospitalet de Llobregat, Barcelona, Spain ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States ; Cancer Prevention and Control Program, Catalan Institute of Oncology, IDIBELL, l'Hospitalet de Llobregat, Barcelona, Spain; Ciber Epidemiologiá y Salud Pública (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain ; Division of Epidemiology and Community Health, University of Minnesota, MN, Minneapolis, United States ; Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain ; Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany ; Department of Genetics, Stanford University, California, Stanford, United States ; Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU) de Nantes, Nantes, France ; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom ; Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah Health, Utah, Salt Lake City, United States ; Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbrücke, Germany ; Centre for Research in Epidemiology and Population Health (CESP), Institut Pour la Santé et la Recherche Médicale (INSERM) U1018, Université Paris-Saclay, Villejuif, France; Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France ; Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Centre (DKFZ), National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany ; Institute of Cancer Research, Department of Medicine i, Medical University of Vienna, Vienna, Austria ; Department of Medicine i, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany ; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Clinical Pathology, the University of Melbourne, VIC, Melbourne, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Melbourne, Australia ; Institute for Health Research, Kaiser Permanente Colorado, CO, Denver, United States ; Division of Research, Kaiser Permanente Medical Care Program, CA, Oakland, United States ; Behavioral and Epidemiology Research Group, American Cancer Society, GA, Atlanta, United States ; Division of Clinical Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany ; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and Mit, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States ; Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany; Cancer Epidemiology Group, University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany ; Department of Cancer Biology and Genetics and the Comprehensive Cancer Center, The Ohio State University, OH, Columbus, United States ; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom ; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia ; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States ; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, ON, Toronto, Canada ; Swog Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States ; Clinical Research Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Medicine, University of Washington School of Medicine, WA, Seattle, United States ; University of Hawai'i Cancer Center, HI, Honolulu, United States ; Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France ; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States ; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea ; Ontario Institute for Cancer Research, ON, Toronto, Canada ; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia ; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States ; Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States ; Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany ; Department of Family Medicine, University of Virginia, VA, Charlottesville, United States ; Institute of Epidemiology, PopGen Biobank, Christian-Albrechts-University Kiel, Kiel, Germany ; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden ; Department of Health Science Research, Mayo Clinic, AZ, Scottsdale, United States ; Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland ; Departments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University, University Hospitals of Cleveland, OH, Cleveland, United States ; Department of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia ; Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, NY, New York, United States; Department of Medicine, Weill Cornell Medical College, NY, New York, United States ; Broad Institute of Harvard and Mit, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Oncologic Pathology, Dana-Farber Cancer Institute, MA, Boston, United States; Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States ; Dipartimento di Medicina Clinica e Chirurgia, University of Naples Federico II, Naples, Italy ; Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, Newfoundland, St. John's, Canada ; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States ; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, MD, Baltimore, United States ; Department of Public Health Sciences, School of Medicine, University of California Davis, CA, Davis, United States ; Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, TN, Nashville, United States ; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel ; School of Public Health, Imperial College London, London, United Kingdom ; Department of General Surgery, University Hospital Rostock, Rostock, Germany ; Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States ; Division of Cancer Control and Population Sciences, National Cancer Institute, MD, Bethesda, United States ; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States ; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, MayoClinic, MN, Rochester, United States ; Hellenic Health Foundation, Athens, Greece; Who Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece ; Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic ; Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Medical Faculty, University of Heidelberg, Heidelberg, Germany ; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden ; Discipline of Genetics, Memorial University of Newfoundland, Newfoundland, St. John's, Canada ; Department of Genome Sciences, University of Washington, WA, Seattle, United States ; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, OH, Cleveland, United States ; Department of Genetics, Stanford University, California, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States ; Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States ; Department of Preventive Medicine, Usc Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, CA, Los Angeles, United States; City of Hope National Medical Center, CA, Duarte, United States ; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States ; Division of Epidemiology, Department of Population Health, New York University School of Medicine, NY, New York, United States ; The Clalit Health Services, Personalized Genomic Service, Carmel Medical Center, Haifa, Israel; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel, 2021

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