Mendelian randomization supports causality between COVID-19 and glaucoma.
In: Medicine (Baltimore, 2024
academicJournal
Zugriff:
To determine whether there is a causal relationship between Corona Virus Disease 2019 (COVID-19) and glaucoma, a 2-sample Mendelian Randomization (MR) design was applied with the main analysis method of inverse-variance-weighted. The reliability of the results was checked using the heterogeneity test, pleiotropy test, and leave-one-out method. Four sets of instrumental variables (IVs) were used to investigate the causality between COVID-19 and glaucoma risk according to data from the IEU Genome Wide Association Study (GWAS). The results showed that 2 sets of COVID-19(RELEASE) were significantly associated with the risk of glaucoma [ID: ebi-a-GCST011071, OR (95% CI) = 1.227 (1.076-1.400), P = .002259; ID: ebi-a-GCST011073: OR (95% CI) = 1.164 (1.022-1.327), P = .022450; 2 sets of COVID-19 hospitalizations were significantly associated with the risk of glaucoma (ID: ebi-a-GCST011081, OR (95% CI) = 1.156 (1.033-1.292), P = .011342; ID: ebi-a-GCST011082: OR (95% CI) = 1.097 (1.007-1.196), P = .034908)]. The sensitivity of the results was acceptable (P > .05) for the 3 test methods. In conclusion, this MR analysis provides preliminary evidence of a potential causal relationship between COVID-19 and glaucoma.
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Mendelian randomization supports causality between COVID-19 and glaucoma.
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Autor/in / Beteiligte Person: | Chen, Maolin ; Zhang, Yinhui ; Yao, Yu ; Huang, Yilan ; Jiang, Longyang |
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Zeitschrift: | Medicine (Baltimore, 2024 |
Veröffentlichung: | Wolters Kluwer, 2024 |
Medientyp: | academicJournal |
DOI: | 10.1097/MD.0000000000038455 |
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