National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio:a pooled analysis of 458 population-based studies in Asian and Western countries
Oxford University Press, 2020
Online
academicJournal
Zugriff:
Background: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. Methods: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. Results: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. Conclusions: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.
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National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio:a pooled analysis of 458 population-based studies in Asian and Western countries
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| Autor/in / Beteiligte Person: | Taddei, C. (Cristina) ; Jackson, R. (Rod) ; Zhou, B. (Bin) ; Bixby, H. (Honor) ; Danaei, G. (Goodarz) ; Di Cesare, M. (Mariachiara) ; Kuulasmaa, K. (Kari) ; Hajifathalian, K. (Kaveh) ; Bentham, J. (James) ; Bennett, J. E. (James E.) ; Aekplakorn, W. (Wichai) ; Cifkova, R. (Renata) ; Dallongeville, J. (Jean) ; DeBacquer, D. (Dirk) ; Giampaoli, S. (Simona) ; Gudnason, V. (Vilmundur) ; Khang, Y.-H. (Young-Ho) ; Laatikainen, T. (Tiina) ; Mann, J. I. (Jim, I) ; Marques-Vidal, P. (Pedro) ; Mensah, G. A. (George A.) ; Mueller-Nurasyid, M. (Martina) ; Ninomiya, T. (Toshiharu) ; Petkeviciene, J. (Janina) ; Rodriguez-Artalejo, F. (Fernando) ; Servais, J. (Jennifer) ; Soderberg, S. (Stefan) ; Stavreski, B. (Bill) ; Wilsgaard, T. (Tom) ; Zdrojewski, T. (Tomasz) ; Zhao, D. (Dong) ; Stevens, G. A. (Gretchen A.) ; Savin, S. (Stefan) ; Cowan, M. J. (Melanie J.) ; Riley, L. M. (Leanne M.) ; Ezzati, M. (Majid) ; Adams, R. J. (Robert J.) ; Ahrens, W. (Wolfgang) ; Amouyel, P. (Philippe) ; Amuzu, A. (Antoinette) ; Anderssen, S. A. (Sigmund A.) ; Ariansen, I. (Inger) ; Arveiler, D. (Dominique) ; Aspelund, T. (Thor) ; Auvinen, J. (Juha) ; Avdicova, M. (Maria) ; Banach, M. (Maciej) ; Bandosz, P. (Piotr) ; Banegas, J. R. (Jose R.) ; Barbagallo, C. M. (Carlo M.) ; Bata, I. (Iqbal) ; Baur, L. A. (Louise A.) ; Beaglehole, R. (Robert) ; Bernotiene, G. (Gailute) ; Bi, Y. (Yufang) ; Bienek, A. (Asako) ; Bjorkelund, C. (Cecilia) ; Bo, S. (Simona) ; Boehm, B. O. (Bernhard O.) ; Bonaccio, M. (Marialaura) ; Bongard, V. (Vanina) ; Borchini, R. (Rossana) ; Borghs, H. (Herman) ; Breckenkamp, J. (Juergen) ; Brenner, H. (Hermann) ; Bruno, G. (Graziella) ; Busch, M. A. (Markus A.) ; Cabrera de Leon, A. (Antonio) ; Capuano, V. (Vincenzo) ; Casanueva, F. F. (Felipe F.) ; Casas, J.-P. (Juan-Pablo) ; Caserta, C. A. (Carmelo A.) ; Censi, L. (Laura) ; Chen, F. (Fangfang) ; Chen, S. (Shuohua) ; Chirlaque, M.-D. (Maria-Dolores) ; Cho, B. (Belong) ; Cho, Y. 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(Xingwang) ; Yoshihara, A. (Akihiro) ; Zambon, S. (Sabina) ; Zhao, W. (Wenhua) |
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| Veröffentlichung: | Oxford University Press, 2020 |
| Medientyp: | academicJournal |
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