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Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers. ; Yes

Titel:	Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis
Autor/in / Beteiligte Person:	Papadimitriou, Nikos ; Dimou, Niki ; Tsilidis, Konstantinos K. ; Banbury, Barbara ; Martin, Richard M. ; Lewis, Sarah J. ; Kazmi, Nabila ; Robinson, Timothy M. ; Albanes, Demetrius ; Aleksandrova, Krasimira ; Berndt, Sonja I. ; Bishop, D. Timothy ; Brenner, Hermann ; Buchanan, Daniel D. ; Bueno-de-Mesquita, Bas ; Campbell, Peter T. ; Castellví-Bel, Sergi ; Chan, Andrew T. ; Chang-Claude, Jenny ; Ellingjord-Dale, Merete ; Figueiredo, Jane C. ; Gallinger, Steven J. ; Giles, Graham G. ; Giovannucci, Edward ; Gruber, Stephen B. ; Gsur, Andrea ; Hampe, Jochen ; Hampel, Heather ; Harlid, Sophia ; Harrison, Tabitha A. ; Hoffmeister, Michael ; Hopper, John L. ; Hsu, Li ; Huerta, José María ; Huyghe, Jeroen R. ; Jenkins, Mark A. ; Keku, Temitope O. ; Kühn, Tilman ; La Vecchia, Carlo ; Le Marchand, Loic ; Li, Christopher I. ; Li, Li ; Lindblom, Annika ; Lindor, Noralane M. ; Lynch, Brigid ; Markowitz, Sanford D. ; Masala, Giovanna ; May, Anne M. ; Milne, Roger ; Monninkhof, Evelyn ; Moreno, Lorena ; Moreno, Victor ; Newcomb, Polly A. ; Offit, Kenneth ; Perduca, Vittorio ; Pharoah, Paul D. P. ; Platz, Elizabeth A. ; Potter, John D. ; Rennert, Gad ; Riboli, Elio ; Sánchez, Maria-Jose ; Schmit, Stephanie L. ; Schoen, Robert E. ; Severi, Gianluca ; Sieri, Sabina ; Slattery, Martha L. ; Song, Mingyang ; Tangen, Catherine M. ; Thibodeau, Stephen N. ; Travis, Ruth C. ; Trichopoulou, Antonia ; Ulrich, Cornelia M. ; van Duijnhoven, Franzel J. B. ; Van Guelpen, Bethany ; Vodicka, Pavel ; White, Emily ; Wolk, Alicja ; Woods, Michael O. ; Wu, Anna H. ; Peters, Ulrike ; Gunter, Marc J. ; Murphy, Neil ; Papadimitriou,N ; Dimou,N ; Gunter,MJ ; Murphy,N Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France. Tsilidis,KK Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece. Tsilidis,KK ; Ellingjord-Dale,M ; Riboli,E Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. Banbury,B ; Harrison,TA ; Hsu,L ; Huyghe,JR ; Li,CI ; Newcomb,PA ; Potter,JD ; White,E ; Peters,U Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Martin,RM ; Kazmi,N MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Martin,RM ; Lewis,SJ, Robinson,TM Bristol Medical School, Department of Population Health Sciences, University of Bristol, Bristol, UK. Martin,RM National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK. Albanes,D ; Berndt,SI Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MA, USA. Aleksandrova,K German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany. Bishop,DT Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK. Brenner,H ; Hoffmeister,M Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Brenner,H Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany. Brenner,H German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. Buchanan,DD ; Giles,GG ; Hopper,JL ; Jenkins,MA ; Lynch,B ; Milne,R Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia. Buchanan,DD Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, VIC, Australia. Buchanan,DD Genetic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, VIC, Australia Bueno-de-Mesquita,B Former senior scientist, Dept. for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), BA Bilthoven, Netherlands. Bueno-de-Mesquita,B Former associate professor, Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, Netherlands. Bueno-de-Mesquita,B ormer visiting professor, Dept. of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, St Mary’s Campus, Norfolk Place, London, London, UK. Bueno-de-Mesquita,B Former academic Icon / visiting professor, Dept. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Pantai Valley, Kuala Lumpur, Malaysia. Campbell,PT Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA. Castellví-Bel,S ; Moreno,L Gastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain. Chan,AT ; Song,M Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Chan,AT ; Song,M Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Chang-Claude,J ; Kühn,T Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Chang-Claude,J University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany. Figueiredo,JC Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Figueiredo,JC Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Gallinger,SJ Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. Giles,GG ; Milne,R Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia. Giovannucci,E ; Song,M Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA. Giovannucci,E ; Song,M Department of Nutrition, T.H. H, Chan School of Public Health, Boston, MA, USA. Giovannucci,E Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA. Gruber,SB ; Schmit,SL Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Gsur,A Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria. Hampe,J Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany. Hampel,H Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. Harlid,S Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden. Hopper,JL Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea. Hsu,L Department of Biostatistics, University of Washington, Seattle, WA, USA. Huerta,JM ; Moreno,V ; Sánchez,MJ CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Huerta,JM Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. Keku,TO Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA. La Vecchia,C ; Trichopoulou,A Hellenic Health Foundation, Athens, Greece. La Vecchia,C Dept. of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy. Le Marchand,L University of Hawaii Cancer Center, Honolulu, HI, USA. Li,L Department of Family Medicine, University of Virginia, Charlottesville, VA, USA. Lindblom,A Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden. Lindblom,A Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Lindor,NM Department of Health Science Research, Mayo Clinic, Scottsdale, AZ, USA. Lynch,B Physical Activity Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia. Markowitz,SD Departments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, OH, USA. Masala,G Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy. May,AM ; Monninkhof,E Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, GA UTRECHT, Netherlands. Milne,R Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, VIC, Australia. Moreno,V Cancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain. Moreno,V Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain. Newcomb,PA School of Public Health, University of Washington, Seattle, WA, USA. Offit,K Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Offit,K Department of Medicine, Weill Cornell Medical College, New York, NY, USA. Perduca,V ; Severi,G CESP, Fac. de médecine - Univ. ParisSud, Fac. de médecine - UVSQ I, Université Paris-Saclay, Villejuif, France. Perduca,V ; Severi,G Gustave Roussy, Villejuif, France. Perduca,V Laboratoire de Mathématiques Appliquées MAP5 (UMR CNRS 8145), Université Paris Descartes, Paris, France. Pharoah,PDP Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Platz,EA Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Rennert,G Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel. Rennert,G 7Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. Rennert,G Clalit National Cancer Control Center, Haifa, Israel. Sánchez,MJ Andalusian School of Public Health, Biomedical Research Institute ibs.GRANADA, University of Granada, Granada, Spain. Schmit,SL Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Schoen,RE Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Sieri,S Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Slattery,ML Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA. Tangen,CM SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Thibodeau,SN Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Travis,RC Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. Ulrich,CM Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA. van Duijnhoven,FJB Division of Human Nutrition, Wageningen University and Research, Wageningen, Netherlands. Van Guelpen,B Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden. Van Guelpen,B Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden. Vodicka,P Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic. Vodicka,P Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic. Vodicka,P Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic. White,E ; Peters,U Department of Epidemiology, University of Washington, Seattle, WA, USA. Wolk,A Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Woods,MO Memorial University of Newfoundland, Discipline of Genetics, St. John’s, Canada. Wu,AH University of Southern California, Preventative Medicine, Los Angeles, CA, USA. ; This work was supported by the National Cancer Institute, the International Agency for Research on Cancer and a Cancer Research UK program grant (C18281/A19169 to RMM, SJL & NK). RMM was supported by the National Institute for Health Research (NIHR) Bristol Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. The funding sources for BCAC, CCFR, GECCO, and CORECT consortia are presented in detail in the appendix in the Supplementary material.
Link:	https://www.nature.com/articles/s41467-020-14389-8 Volltext https://doi.org/10.1038/s41467-020-14389-8
Veröffentlichung:	Springer Nature, 2020
Medientyp:	academicJournal
ISSN:	2041-1723 (print)
DOI:	10.1038/s41467-020-14389-8
Schlagwort:	Exercise Breast neoplasms Colorectal neoplasms Risk factors Analyses Ejercicio físico Neoplasias de la mama Neoplasias colorrectales Factores de riesgo Medical Subject Headings::Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Accelerometry Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Colorectal Neoplasms Hereditary Nonpolyposis Medical Subject Headings::Check Tags::Female Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Odds Ratio Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism Genetic::Polymorphism Single Nucleotide Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors Medical Subject Headings::Anthropology Education Sociology and Social Phenomena::Human Activities::Exercise Medical Subject Headings::Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Molecular Epidemiology::Mendelian Randomization Analysis
Sonstiges:	Nachgewiesen in: BASE Sprachen: English Collection: Sistema Sanitario Público de Andalucía (SSPA): Repositorio Document Type: article in journal/newspaper File Description: application/pdf Language: English Rights: Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0/ ; Acceso abierto

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Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis