Association of Genomic Domains in and with Prostate Cancer Risk and Aggressiveness. ; Association of Genomic Domains in BRCA1 and BRCA2 With Prostate Cancer Risk and Aggressiveness
In: Cancer research ; 80 ; 3 ; 624 ; 638 ; United Kingdom ; United States, 2020
Online
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Zugriff:
To access publisher's full text version of this article click on the hyperlink below ; Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3' region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71-4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12-11.54; P = 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. SIGNIFICANCE: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual. ; National Health and Medical Research Council of Australia National Breast Cancer Foundation Cancer Australia United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Cancer Institute (NCI) Cancer Research UK European Community (EC) United States Department of Health & Human Services National Institutes of Health (NIH) - USA Post-Cancer GWAS initiative - the GAME-ON initiative United States Department of Defense Canadian Institutes of Health Research (CIHR) Ministry of Economic Development, Innovation and Export Trade Susan G. Komen Breast Cancer Foundation Breast Cancer Research ...
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Association of Genomic Domains in and with Prostate Cancer Risk and Aggressiveness. ; Association of Genomic Domains in BRCA1 and BRCA2 With Prostate Cancer Risk and Aggressiveness
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| Autor/in / Beteiligte Person: | Patel, Vivek L ; Busch, Evan L ; Friebel, Tara M ; Cronin, Angel ; Leslie, Goska ; McGuffog, Lesley ; Adlard, Julian ; Agata, Simona ; Agnarsson, Bjarni A ; Ahmed, Munaza ; Aittomäki, Kristiina ; Alducci, Elisa ; Andrulis, Irene L ; Arason, Adalgeir ; Arnold, Norbert ; Artioli, Grazia ; Arver, Brita ; Auber, Bernd ; Azzollini, Jacopo ; Balmaña, Judith ; Barkardottir, Rosa B ; Barnes, Daniel R ; Barroso, Alicia ; Barrowdale, Daniel ; Belotti, Muriel ; Benitez, Javier ; Bertelsen, Brigitte ; Blok, Marinus J ; Bodrogi, Istvan ; Bonadona, Valérie ; Bonanni, Bernardo ; Bondavalli, Davide ; Boonen, Susanne E ; Borde, Julika ; Borg, Ake ; Bradbury, Angela R ; Brady, Angela ; Brewer, Carole ; Brunet, Joan ; Buecher, Bruno ; Buys, Saundra S ; Cabezas-Camarero, Santiago ; Caldés, Trinidad ; Caliebe, Almuth ; Caligo, Maria A ; Calvello, Mariarosaria ; Campbell, Ian G ; Carnevali, Ileana ; Carrasco, Estela ; Chan, Tsun L ; Chu, Annie T W ; Chung, Wendy K ; Claes, Kathleen B M ; Collaborators, Gemo Study ; Collaborators, Embrace ; Cook, Jackie ; Cortesi, Laura ; Couch, Fergus J ; Daly, Mary B ; Damante, Giuseppe ; Darder, Esther ; Davidson, Rosemarie ; de la Hoya, Miguel ; Puppa, Lara Della ; Dennis, Joe ; Díez, Orland ; Ding, Yuan Chun ; Ditsch, Nina ; Domchek, Susan M ; Donaldson, Alan ; Dworniczak, Bernd ; Easton, Douglas F ; Eccles, Diana M ; Eeles, Rosalind A ; Ehrencrona, Hans ; Ejlertsen, Bent ; Engel, Christoph ; Evans, D Gareth ; Faivre, Laurence ; Faust, Ulrike ; Feliubadaló, Lídia ; Foretova, Lenka ; Fostira, Florentia ; Fountzilas, George ; Frost, Debra ; García-Barberán, Vanesa ; Garre, Pilar ; Gauthier-Villars, Marion ; Géczi, Lajos ; Gehrig, Andrea ; Gerdes, Anne-Marie ; Gesta, Paul ; Giannini, Giuseppe ; Glendon, Gord ; Godwin, Andrew K ; Goldgar, David E ; Greene, Mark H ; Gutierrez-Barrera, Angelica M ; Hahnen, Eric ; Hamann, Ute ; Hauke, Jan ; Herold, Natalie ; Hogervorst, Frans B L ; Honisch, Ellen ; Hopper, John L ; Hulick, Peter J ; Investigators, KConFab ; Investigators, Hebon ; Izatt, Louise ; Jager, Agnes ; James, Paul ; Janavicius, Ramunas ; Jensen, Uffe Birk ; Jensen, Thomas Dyrso ; Johannsson, Oskar Th ; John, Esther M ; Joseph, Vijai ; Kang, Eunyoung ; Kast, Karin ; Kiiski, Johanna I ; Kim, Sung-Won ; Kim, Zisun ; Ko, Kwang-Pil ; Konstantopoulou, Irene ; Kramer, Gero ; Krogh, Lotte ; Kruse, Torben A ; Kwong, Ava ; Larsen, Mirjam ; Lasset, Christine ; Lautrup, Charlotte ; Lazaro, Conxi ; Lee, Jihyoun ; Lee, Jong Won ; Lee, Min Hyuk ; Lemke, Johannes ; Lesueur, Fabienne ; Liljegren, Annelie ; Lindblom, Annika ; Llovet, Patricia ; Lopez-Fernández, Adria ; Lopez-Perolio, Irene ; Lorca, Victor ; Loud, Jennifer T ; Ma, Edmond S K ; Mai, Phuong L ; Manoukian, Siranoush ; Mari, Veronique ; Martin, Lynn ; Matricardi, Laura ; Mebirouk, Noura ; Medici, Veronica ; Meijers-Heijboer, Hanne E J ; Meindl, Alfons ; Mensenkamp, Arjen R ; Miller, Clare ; Gomes, Denise Molina ; Montagna, Marco ; Mooij, Thea M ; Moserle, Lidia ; Mouret-Fourme, Emmanuelle ; Mulligan, Anna Marie ; Nathanson, Katherine L ; Navratilova, Marie ; Nevanlinna, Heli ; Niederacher, Dieter ; Nielsen, Finn C Cilius ; Nikitina-Zake, Liene ; Offit, Kenneth ; Olah, Edith ; Olopade, Olufunmilayo I ; Ong, Kai-Ren ; Osorio, Ana ; Ott, Claus-Eric ; Palli, Domenico ; Park, Sue K ; Parsons, Michael T ; Pedersen, Inge Sokilde ; Peissel, Bernard ; Peixoto, Ana ; Pérez-Segura, Pedro ; Peterlongo, Paolo ; Petersen, Annabeth Høgh ; Porteous, Mary E ; Pujana, Miguel Angel ; Radice, Paolo ; Ramser, Juliane ; Rantala, Johanna ; Rashid, Muhammad U ; Rhiem, Kerstin ; Rizzolo, Piera ; Robson, Mark E ; Rookus, Matti A ; Rossing, Caroline M ; Ruddy, Kathryn J ; Santos, Catarina ; Saule, Claire ; Scarpitta, Rosa ; Schmutzler, Rita K ; Schuster, Hélène ; Senter, Leigha ; Seynaeve, Caroline M ; Shah, Payal D ; Sharma, Priyanka ; Shin, Vivian Y ; Silvestri, Valentina ; Simard, Jacques ; Singer, Christian F ; Skytte, Anne-Bine ; Snape, Katie ; Solano, Angela R ; Soucy, Penny ; Southey, Melissa C ; Spurdle, Amanda B ; Steele, Linda ; Steinemann, Doris ; Stoppa-Lyonnet, Dominique ; Stradella, Agostina ; Sunde, Lone ; Sutter, Christian ; Tan, Yen Y ; Teixeira, Manuel R ; Teo, Soo Hwang ; Thomassen, Mads ; Tibiletti, Maria Grazia ; Tischkowitz, Marc ; Tognazzo, Silvia ; Toland, Amanda E ; Tommasi, Stefania ; Torres, Diana ; Toss, Angela ; Trainer, Alison H ; Tung, Nadine ; van Asperen, Christi J ; van der Baan, Frederieke H ; van der Kolk, Lizet E ; van der Luijt, Rob B ; van Hest, Liselotte P ; Varesco, Liliana ; Varon-Mateeva, Raymonda ; Viel, Alessandra ; Vierstrate, Jeroen ; Villa, Roberta ; von Wachenfeldt, Anna ; Wagner, Philipp ; Wang-Gohrke, Shan ; Wappenschmidt, Barbara ; Weitzel, Jeffrey N ; Wieme, Greet ; Yadav, Siddhartha ; Yannoukakos, Drakoulis ; Yoon, Sook-Yee ; Zanzottera, Cristina ; Zorn, Kristin K ; D'Amico, Anthony V ; Freedman, Matthew L ; Pomerantz, Mark M ; Chenevix-Trench, Georgia ; Antoniou, Antonis C ; Neuhausen, Susan L ; Ottini, Laura ; Nielsen, Henriette Roed ; 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Chan School of Public Health, Boston, Massachusetts. 3Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. 4Dana-Farber Cancer Institute. Boston, Massachusetts. 5Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. 6Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom. 7Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy. 8Department of Pathology, Landspitali University Hospital, 101, Reykjavik, Iceland. 9School of Medicine, University of Iceland, Reykjavik, Iceland. 10North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom. 11Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 12Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada. 13Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. 14BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 15Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany. 16ULSS 3 Serenissima, U.O.C. Oncologia ed Ematologia Oncologica, Mirano, Venice, Italy. 17Department of Oncology, Karolinska Institutet, Stockholm, Sweden. 18Institute of Human Genetics, Hannover Medical School, Hannover, Germany. 19Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori di Milano, Milan, Italy. 20High Risk and Cancer Prevention Group, Vall d'Hebron Institute of Oncology, University Hospital Vall d'Hebron, Barcelona, Spain. 21Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. 22Service de Génétique, Institut Curie, Paris, France. 23Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. 24Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. 25Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 26Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands. 27Department of Chemotherapy, National Institute of Oncology, Budapest, Hungary. 28Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France. 29Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan, Italy. 30Clinical Genetic Unit, Department of Paediatrics, Zealand University Hospital, Roskilde, Denmark. 31Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany. 32Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. 33Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany. 34Department of Oncology, Lund University and Skåne University Hospital, Lund, Sweden. 35Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. 36North West Thames Regional Genetics Service, Kennedy Galton Centre, The North West London Hospitals NHS Trust, Middlesex, United Kingdom. 37Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, United Kingdom. 38Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain. 39Department of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah. 40Department of Oncology, Hospital Clinico San Carlos, IdISSC, Madrid, Spain. 41Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. 42Institute of Human Genetics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany. 43Section of Molecular Genetics, Department of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy. 44Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. 45Sir Peter 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Genetics, South Glasgow University Hospitals, Glasgow, United Kingdom. 57Division of Functional Onco-genomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy. 58Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Barcelona, Spain. 59Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California. 60Department of Gynecology and Obstetrics, Ludwig Maximilian University of Munich, Munich, Germany. 61Clinical Genetics Department, St Michael's Hospital, Bristol, United Kingdom. 62Institute of Human Genetics, University of Münster, Münster, Germany. 63Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom. 64Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. 65Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, United Kingdom. 66Department of Clinical Genetics, Lund University Hospital, Lund, Sweden. 67Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 68Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 69LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. 70Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health and Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom. 71Manchester Centre for Genomic Medicine, St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust and Manchester Academic Health Science Centre, Manchester, United Kingdom. 72Unité d'oncogénétique, Centre de Lutte Contre le Cancer, Centre Georges-François Leclerc, Dijon, France. 73Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany. 74Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain. 75Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic. 76Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Athens, Greece. 77Second Department of Medical Oncology, EUROMEDICA General Clinic of Thessaloniki, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece. 78Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University of Würzburg, Würzburg, Germany. 79Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark. 80Service Régional Oncogénétique Poitou-Charentes, CH Niort, Niort, France. 81Department of Molecular Medicine, University La Sapienza, Rome, Italy. 82Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, Kansas. 83Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah. 84Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland. 85Department of Breast Medical Oncology and Clinical Genetics Program, University of Texas MD Anderson Cancer Center, Houston, Texas. 86Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. 87Family Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands. 88Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany. 89Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. 90Center for Medical Genetics, NorthShore University HealthSystem, Evanston, Illinois. 91The University of Chicago Pritzker School of Medicine, Chicago, Illinois. 92The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), Coordinating center: The Netherlands Cancer Institute, Amsterdam, the Netherlands. 93Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. 94Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands. 95Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. 96Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania. 97Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark. 98Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark. 99Department of Oncology, Landspitali University Hospital, Reykjavik, Iceland. 100Division of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California. 101Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York. 102Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea. 103Department of Gynecology and Obstetrics, Technical University of Dresden, Dresden, Germany. 104Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 105Department of Surgery, Daerim Saint Mary's Hospital, Seoul, Korea. 106Department of Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. 107Department of Preventive Medicine, Gacheon University College of Medicine, Incheon, Republic of Korea. 108Department of Urology, Medical University of Vienna, Vienna, Austria. 109Department of Clinical Genetics, Odense University Hospital, Odense, Denmark. 110Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong. 111Department of Surgery, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong. 112Department of Clinical Genetics, Aalborg University Hospital, Aalborg, Denmark. 113Department of Surgery, Soonchunhyang University College of Medicine and Soonchunhyang University Hospital, Seoul, Korea. 114Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, Korea. 115Institute of Human Genetics, University Hospital Leipzig, Leipzig, Germany. 116Genetic Epidemiology of Cancer Team, Inserm U900, Paris, France. 117Institut Curie, Paris, France. 118Mines ParisTech, Fontainebleau, France. 119Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. 120Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden. 121Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. 122Département d'Hématologie-Oncologie Médicale, Centre Antoine Lacassagne, Nice, France. 123Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom. 124Department of Clinical Genetics, VU University Medical Center, Amsterdam, the Netherlands. 125Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands. 126Department of Clinical Genetics, Alder Hey Hospital, Liverpool, United Kingdom. 127Service de Biologie de la Reproduction, Cytogénétique et Génétique Médicale, CHI Poissy - Saint Germain, Poissy, France. 128Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. 129Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. 130Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada. 131Latvian Biomedical Research and Study Centre, Riga, Latvia. 132Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York. 133Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary. 134Center for Clinical Cancer Genetics, The University of Chicago, Chicago, Illinois. 135West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, United Kingdom. 136Institute for Medical Genetics and Human Genetics, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. 137Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy. 138Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. 139Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea. 140Cancer Research Institute, Seoul National University, Seoul, Korea. 141Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 142Section of Molecular Diagnostics, Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark. 143Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. 144Genome Diagnostics Program, IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy. 145South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, United Kingdom. 146Translational Research Laboratory, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain. 147Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, in Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy. 148Division of Gynaecology and Obstetrics, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany. 149Clinical Genetics, Karolinska Institutet, Stockholm, Sweden. 150Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC), Lahore, Pakistan. 151Department of Oncology, Mayo Clinic, Rochester, Minnesota. 152Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy. 153Unité d'Oncogénétique, Centre de Lutte Contre le Cancer Paul Strauss, Strasbourg, France. 154Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio. 155Department of Internal Medicine, Division of Oncology, University of Kansas Medical Center, Westwood, Kansas. 156Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval, Research Centre, Québec City, Québec, Canada. 157Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. 158Medical Genetics Unit, St George's, University of London, London, United Kingdom. 159INBIOMED, Faculty of Medicine/CONICET and CEMIC, Department of Clinical Chemistry, Medical Direction, University of Buenos Aires, Buenos Aires, Argentina. 160Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia. 161Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia. 162Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany. 163Department of Tumour Biology, INSERM U830, Paris, France. 164Université Paris Descartes, Paris, France. 165Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain. 166Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany. 167Department of OB/GYN, Medical University of Vienna, Vienna, Austria. 168Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal. 169Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia. 170Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia. 171Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, Quebec, Canada. 172Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom. 173Department of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio. 174Istituto Nazionale Tumori 'Giovanni Paolo II, Bari, Italy. 175Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia. 176Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts. 177Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands. 178Department of Medical Genetics, University Medical Center, Utrecht, the Netherlands. 179Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. 180Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) AOU San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy. 181Department of Women's Health, Tubingen University Hospital, Tubingen, Germany. 182Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany. 183Clinical Cancer Genetics, City of Hope, Duarte, California. 184Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Selangor, Malaysia. 185Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Timothy_Rebbeck@dfci.harvard.edu. |
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| Zeitschrift: | Cancer research ; 80 ; 3 ; 624 ; 638 ; United Kingdom ; United States, 2020 |
| Veröffentlichung: | American Association for Cancer Research, 2020 |
| Medientyp: | academicJournal |
| ISSN: | 1538-7445 (print) |
| DOI: | 10.1158/0008-5472.CAN-19-1840 |
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