Clinical Relevance of a 16-Gene Pharmacogenetic Panel Test for Medication Management in a Cohort of 135 Patients
In: Journal of Clinical Medicine, 10 (15, 2021
Online
academicJournal
Zugriff:
There is a growing number of evidence-based indications for pharmacogenetic (PGx) testing. We aimed to evaluate clinical relevance of a 16-gene panel test for PGx-guided pharmacotherapy. In an observational cohort study, we included subjects tested with a PGx panel for variants of ABCB1, COMT, CYP1A2, CYP2B6, CYP3A4, CYP3A5, CYP2C9, CYP2C19, CYP2D6, CYP4F2, DPYD, OPRM1, POR, SLCO1B1, TPMT and VKORC1. PGx-guided pharmacotherapy management was supported by the PGx expert system SONOGEN XP. The primary study outcome was PGx-based changes and recommendations regarding current and potential future medication. PGx-testing was triggered by specific drug-gene pairs in 102 subjects, and by screening in 33. Based on PharmGKB expert guidelines we identified at least one "actionable" variant in all 135 (100%) tested patients. Drugs that triggered PGx-testing were clopidogrel in 60, tamoxifen in 15, polypsychopharmacotherapy in 9, opioids in 7, and other in 11 patients. Among those, PGx variants resulted in clinical recommendations to change PGx-triggering drugs in 33 (32.4%), and other current pharmacotherapy in 23 (22.5%). Additional costs of panel vs. single gene tests are moderate, and the efficiency of PGx panel testing challenges traditional cost-benefit calculations for single drug-gene pairs. However, PGx-guided pharmacotherapy requires specialized expert consultations with interdisciplinary collaborations. ; ISSN:2077-0383
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Clinical Relevance of a 16-Gene Pharmacogenetic Panel Test for Medication Management in a Cohort of 135 Patients
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Autor/in / Beteiligte Person: | Niedrig, David F. ; Rahmany, Ali ; Heib, Kai ; Hatz, Karl-Dietrich ; Ludin, Katja ; Burden, Andrea ; 000-0001-7082-8530, id_orcid:0 ; Béchir, Markus ; Serra, Andreas ; Russmann, Stefan |
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Zeitschrift: | Journal of Clinical Medicine, 10 (15, 2021 |
Veröffentlichung: | MDPI, 2021 |
Medientyp: | academicJournal |
DOI: | 10.3929/ethz-b-000500774 |
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