Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia
Ireland, Elsevier, 2016
academicJournal
Zugriff:
Frontotemporal dementia (FTD) presents clinically with behavioral changes including disinhibition. Mutations in the tau-encoding MAPT gene identified in familial cases of FTD have been used to generate transgenic mouse models of the human condition. Here, we report behavioral changes in a recently developed P301S mutant tau transgenic mouse, including disinhibition-like behavior in the elevated plus maze and hyperactivity in the open field arena. Furthermore, histological analysis revealed the amygdala as a primary and early site of pathological tau deposition in these mice. Taken together, neuropathological and behavioral changes in P301S tau transgenic mice resemble features of human FTD.
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Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia
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Autor/in / Beteiligte Person: | Przybyla, Magdalena ; Stevens, Claire H. ; Hoven, Julia van der ; Harasta, Anne E. ; Bi, Mian ; Ittner, Arne ; Hummel, Annika van ; Hodges, John R. ; Piguet, Olivier ; Karl, Tim (R18316) ; Kassiou, Michael ; Housley, Gary D. ; Ke, Yazi D. ; Ittner, Lars M. ; Eersel, Janet van ; School of Medicine (Host institution) |
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Veröffentlichung: | Ireland, Elsevier, 2016 |
Medientyp: | academicJournal |
DOI: | 10.1016/j.neulet.2016.08.007 |
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