123I-MIBG myocardial scintigraphy for the diagnosis of DLB: a multicentre 3-year follow-up study
BMJ Publishing Group Ltd, 2018
academicJournal
Zugriff:
Background and purpose We previously reported the usefulness of iodine-123 metaiodobenzylguanidine (123I-MIBG) myocardial scintigraphy for differentiation of dementia with Lewy bodies (DLB) from Alzheimer’s disease (AD) in a cross-sectional multicentre study. The aim of this study was, by using reassessed diagnosis after 3-year follow-up, to evaluate the diagnostic accuracy of 123I-MIBG scintigraphy in differentiation of probable DLB from probable AD. Methods We undertook 3-year follow-up of 133 patients with probable or possible DLB or probable AD who had undergone 123I-MIBG myocardial scintigraphy at baseline. An independent consensus panel made final diagnosis at 3-year follow-up. Based on the final diagnosis, we re-evaluated the diagnostic accuracy of 123I-MIBG scintigraphy performed at baseline. Results Sixty-five patients completed 3-year follow-up assessment. The final diagnoses were probable DLB (n=30), possible DLB (n=3) and probably AD (n=31), and depression (n=1). With a receiver operating characteristic curve analysis of heart-to-mediastinum (H/M) ratios for differentiating probable DLB from probable AD, the sensitivity/specificity were 0.77/0.94 for early images using 2.51 as the threshold of early H/M ratio, and 0.77/0.97 for delayed images using 2.20 as the threshold of delayed H/M ratio. Five of six patients who were diagnosed with possible DLB at baseline and with probable DLB at follow-up had low H/M ratio at baseline. Conclusions Our follow-up study confirmed high correlation between abnormal cardiac sympathetic activity evaluated with 123I-MIBG myocardial scintigraphy at baseline and the clinical diagnosis of probable DLB at 3-year follow-up. Its diagnostic usefulness in early stage of DLB was suggested. Trial registration number UMIN00003419.
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123I-MIBG myocardial scintigraphy for the diagnosis of DLB: a multicentre 3-year follow-up study
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Autor/in / Beteiligte Person: | Komatsu, Junji ; Samuraki, Miharu ; Nakajima, Kenichi ; Arai, Heii ; Arai, Hiroyuki ; Arai, Tetsuaki ; Asada, Takashi ; Fujishiro, Hiroshige ; Hanyu, Haruo ; Iizuka, Osamu ; Iseki, Eizo ; Kashihara, Kenichi ; Kosaka, Kenji ; Maruno, Hirotaka ; Mizukami, Katsuyoshi ; Mizuno, Yoshikuni ; Mori, Etsuro ; Nakamura, Hiroyuki ; Nakano, Seigo ; Nakashima, Kenji ; Nishio, Yoshiyuki ; Orimo, Satoshi ; Takahashi, Akira ; Taki, Junichi ; Tokuda, Takahiko ; Urakami, Katsuya ; Utsumi, Kumiko ; Wada, Kenji ; Washimi, Yukihiko ; Yamashina, Shouhei ; Yamasaki, Junichi ; Yoshita, Mitsuhiro ; Yamada, Masahito |
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Veröffentlichung: | BMJ Publishing Group Ltd, 2018 |
Medientyp: | academicJournal |
DOI: | 10.1136/jnnp-2017-317398 |
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