Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment

Morra, Anna ; Escala-Garcia, Maria ; et al.

Uppsala universitet, Medicinsk epidemiologi ; Antoni van Leeuwenhoek Hosp, Div Mol Pathol, Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands. ; QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia. ; Antoni van Leeuwenhoek Hosp, Div Mol Pathol, Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands.;Antoni van Leeuwenhoek Hosp, Div Mol Carcinogenesis, Netherlands Canc Inst, Amsterdam, Netherlands. ; NCI, US Dept HHS, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. ; Fred A Litwin Ctr Canc Genet, Lunenfeld Tanenbaum Res Inst Mt Sinai Hosp, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada. ; Univ Calif Irvine, Dept Med, Genet Epidemiol Res Inst, Irvine, CA 92717 USA. ; German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany. ; Fred Hutchinson Canc Res Ctr, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Wisconsin, Zilber Sch Publ Hlth, Milwaukee, WI 53201 USA. ; Lund Univ, Dept Canc Epidemiol, Clin Sci, Lund, Sweden. ; Univ Med Ctr Hamburg Eppendorf, Inst Med Biometry & Epidemiol, Hamburg, Germany. ; Friedrich Alexander Univ Erlangen Nuremberg FAU, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Dept Gynecol & Obstet, Erlangen, Germany. ; German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany. ; Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark. ; Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England. ; German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.;Natl Ctr Tumor Dis NCT, Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany. ; Inst Ruhr Univ Bochum IPA, Inst Prevent & Occupat Med, German Social Accid Insurance, Bochum, Germany. ; Huntsman Canc Inst, Dept Med, Salt Lake City, UT USA. ; Kaiser Permanente, Div Res, Oakland, CA USA. ; German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Univ Pisa, Dept Biol, Pisa, Italy. ; German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany. ; Xerencia Xest Integrada Vigo SERGAS, Oncol & Genet Unit, Inst Invest Sanitaria Galicia Sur IISGS, Vigo, Spain. ; German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Univ Med Ctr Hamburg Eppendorf, Univ Canc Ctr Hamburg UCCH, Canc Epidemiol Grp, Hamburg, Germany. ; Roswell Park Canc Inst, Div Canc Prevent & Control, Buffalo, NY 14263 USA. ; Univ Sydney, Westmead Inst Med Res, Sydney, NSW, Australia. Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, Radiumhosp, Oslo, Norway. ; Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA. ; Univ Sheffield, Sheffield Inst Nucle Acids SInFoNiA, Dept Oncol & Metab, Sheffield, S Yorkshire, England. ; Univ Sheffield, Acad Unit Pathol, Dept Neurosci, Sheffield, S Yorkshire, England. ; Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. ; Fox Chase Canc Ctr, Dept Clin Genet, 7701 Burholme Ave, Philadelphia, PA 19111 USA. ; Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany. ; Int Agcy Res Canc IARC WHO, Nutr & Metab Sect, Lyon, France. ; Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England. ; Univ Westminster, Sch Life Sci, London, England. ; Univ Southampton, Fac Med, Southampton, Hants, England. ; Friedrich Alexander Univ Erlangen Nuremberg FAU, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Inst Human Genet, Erlangen, Germany. ; Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Channing Div Network Med, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA. ; Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Sch Biol Sci,Div Evolut & Genom Sci, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, St Marys Hosp, Manchester Acad Hlth Sci Ctr, North West Genom Lab Hub,Manchester Ctr Genom Med, Manchester, Lancs, England. ; Friedrich Alexander Univ Erlangen Nuremberg FAU, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Dept Gynecol & Obstet, Erlangen, Germany.;Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Hematol & Oncol, Los Angeles, CA 90095 USA. ; Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Breast Surg, Herlev, Denmark. ; Curtin Univ, Sch Publ Hlth, Perth, WA, Australia. ; Galician Publ Fdn Genom Med FPGMX, Hlth Res Inst Santiago IDIS, Int Canc Genet & Epidemiol Grp, Genom Med Grp, Santiago De Compostela, Spain.;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA. ; Hosp Clin San Carlos, Ctr Invest Biomed Red Canc CIBERONC, Inst Invest Sanitaria San Carlos IdISSC, Med Oncol Dept, Madrid, Spain. ; Canc Council Victoria, Canc Epidemiol Div, Victoria, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Victoria, Australia.;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia. ; Univ Oulu, Oulu Univ Hosp, Dept Surg, Oulu, Finland. ; Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP, INSERM, Team Exposome & Hered, Villejuif, France. ; German Canc Res Ctr, Mol Epidemiol Grp, C080, Heidelberg, Germany.;Heidelberg Univ, Univ Womens Clin Heidelberg, Mol Biol Breast Canc, Heidelberg, Germany.;Helmholtz Zentrum Munchen, Inst Diabet Res, German Res Ctr Environm Hlth, Neuherberg, Germany. ; Univ Cologne, Fac Med, Cologne, Germany.;Univ Cologne, Univ Hosp Cologne, Ctr Integrated Oncol CIO, Cologne, Germany. ; Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA. ; Karolinska Inst, Inst Environm Med, Stockholm, Sweden. ; Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Soder Sjukhuset, Dept Oncol, Stockholm, Sweden. ; German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany. ; Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA. ; Univ Eastern Finland, Translat Canc Res Area, Kuopio, Finland.;Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, Kuopio, Finland. ; Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen Nuremberg, Inst Pathol, Erlangen, Germany. ; Erasmus MC Canc Inst, Dept Med Oncol, Rotterdam, Netherlands. ; Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany.;Univ Tubingen, Tubingen, Germany. ; Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Victoria, Australia. ; Univ Manchester, Div Canc Sci, Manchester, Lancs, England. ; Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England. ; Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland.;Pomeranian Med Univ, Independent Lab Mol Biol & Genet Diagnost, Szczecin, Poland. ; Univ Hosp Ulm, Dept Gynaecol & Obstet, Ulm, Germany. ; Stanford Univ, Dept Epidemiol & Populat Hlth, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Canc Inst, Dept Med, Div Oncol,Sch Med, Stanford, CA 94305 USA. ; Univ Leuven, Univ Hosp Leuven, Dept Radiat Oncol, Leuven, Belgium. ; NCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD 20892 USA. ; Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA. ; Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway. Vestre Viken Hosp, Dept Res, Drammen, Norway. Oslo Univ Hosp Ulleval, Dept Canc, Div Surg Canc & Transplantat Med, Sect Breast & Endocrine Surg, Oslo, Norway. Oslo Univ Hosp, Dept Radiol & Nucl Med, Oslo, Norway. Akershus Univ Hosp, Dept Pathol, Lorenskog, Norway. Oslo Univ Hosp, Inst Canc Res, Dept Tumor Biol, Oslo, Norway. Oslo Univ Hosp, Dept Oncol, Div Surg Canc & Transplantat Med, Radiumhosp, Oslo, Norway. Oslo Univ Hosp, Natl Advisory Unit Late Effects Canc Treatment, Radiumhosp, Oslo, Norway. Akershus Univ Hosp, Dept Oncol, Lorenskog, Norway. Oslo Univ Hosp, Breast Canc Res Consortium, Oslo, Norway.;Oslo Univ Hosp, Dept Med Genet, Oslo, Norway.;Univ Oslo, Oslo, Norway. ; City Hope Natl Med Ctr, Dept Computat & Quantitat Med, Duarte, CA USA.;City Hope Natl Med Ctr, City Hope Comprehens Canc Ctr, Duarte, CA USA. ; VIB Ctr Canc Biol, Leuven, Belgium.;Univ Leuven, Dept Human Genet, Lab Translat Genet, Leuven, Belgium. ; Univ Hawaii, Canc Ctr, Epidemiol Program, Honolulu, HI 96822 USA. ; Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden. ; Univ Cambridge, Dept Publ Hlth & Primary Care, Clin Gerontol, Cambridge, England. ; Univ Eastern Finland, Translat Canc Res Area, Kuopio, Finland.;Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, Kuopio, Finland.;Kuopio Univ Hosp, Biobank Eastern Finland, Kuopio, Finland. ; Soder Sjukhuset, Dept Oncol, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden. ; Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA. ; Univ Hosp Heraklion, Dept Med Oncol, Iraklion, Greece. ; Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.;Cyprus Inst Neurol & Genet, Biostat Unit, Nicosia, Cyprus.;Cyprus Sch Mol Med, Cyprus Inst Neurol & Genet, Nicosia, Cyprus. ; Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.;Univ Hlth Network, Lab Med Program, Toronto, ON, Canada. ; Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Helsinki, Finland. ; Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark. ; Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.;Univ N Carolina, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA. ; Queens Univ Belfast, Ctr Canc Res & Cell Biol, Belfast, Antrim, North Ireland. ; Amer Canc Soc, Dept Populat Sci, Atlanta, GA 30329 USA. ; Fdn IRCCS Ist Nazl Tumori Milano, Dept Med Oncol & Hematol, Unit Med Genet, Milan, Italy. ; IFOM FIRC Inst Mol Oncol, Genome Diagnost Program, Milan, Italy. ; Res Ctr Genet Engn & Biotechnol Georgi D Efremov, MASA, Skopje, North Macedonia. ; Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland. ; Fred Hutchinson Canc Res Ctr, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA. ; Carmel Hosp, Haifa, Israel.;Technion Fac Med, Clalit Natl Canc Control Ctr, Haifa, Israel. ; Hosp Univ Puerta de Hierro, Med Oncol Dept, Madrid, Spain. ; UCLH Fdn Trust, Dept Oncol, London, England. ; Univ Hosp Larissa, Dept Oncol, Larisa, Greece. ; Kings Coll London, Comprehens Canc Ctr, Sch Canc & Pharmaceut Sci, Guys Campus, London, England. ; Univ Cologne, Fac Med, Cologne, Germany.;Univ Cologne, Univ Hosp Cologne, Ctr Integrated Oncol CIO, Cologne, Germany.;Univ Cologne, Fac Med, Ctr Mol Med Cologne CMMC, Cologne, Germany.;Univ Cologne, Univ Hosp Cologne, Ctr Mol Med Cologne CMMC, Cologne, Germany. ; Heidelberg Univ, Univ Womens Clin Heidelberg, Mol Biol Breast Canc, Heidelberg, Germany.;Univ Hosp, Heidelberg, Germany.;German Canc Res Ctr, Natl Ctr Tumor Dis, Heidelberg, Germany. ; Ss Cyril & Methodius Univ Skopje, Univ Clin Radiotherapy & Oncol, Med Fac, Skopje, North Macedonia. ; Canc Council Victoria, Canc Epidemiol Div, Victoria, Australia.;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia.;Univ Melbourne, Dept Clin Pathol, Melbourne, Vic, Australia. ; Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Victoria, Australia.;Univ Western Australia, Sch Populat & Global Hlth, Genet Epidemiol Grp, Perth, WA, Australia. ; German Canc Res Ctr, Mol Epidemiol Grp, C080, Heidelberg, Germany.;Heidelberg Univ, Univ Womens Clin Heidelberg, Mol Biol Breast Canc, Heidelberg, Germany. ; Inst Canc Res, Div Genet & Epidemiol, London, England.;Inst Canc Res, Div Breast Canc Res, London, England. ; Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Weill Cornell Med, Dept Populat Hlth Sci, New York, NY USA. ; Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA. ; Leiden Univ Med Ctr, Dept Surg, Leiden, Netherlands. ; Univ Birmingham, Inst Canc & Genom Sci, Birmingham, W Midlands, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford NIHR Biomed Res Ctr, Oxford, England. ; Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA. ; Univ Oulu, Bioctr Oulu, Canc & Translat Med Res Unit, Lab Canc Genet & Tumor Biol, Oulu, Finland.;Northern Finland Lab Ctr Oulu, Lab Canc Genet & Tumor Biol, Oulu, Finland. ; Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany.;Univ Tubingen, iFIT Cluster Excellence, Tubingen, Germany.;German Canc Res Ctr, Tubingen, Germany.;German Canc Consortium DKTK, Partner Site Tubingen, Tubingen, Germany. ; Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England. ; Antoni van Leeuwenhoek Hosp, Div Mol Pathol, Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands.;Antoni van Leeuwenhoek Hosp, Div Psychosocial Res & Epidemiol, Netherlands Canc Inst, Amsterdam, Netherlands. ; BMC, 2021

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Background Given the high heterogeneity among breast tumors, associations between common germline genetic variants and survival that may exist within specific subgroups could go undetected in an unstratified set of breast cancer patients. Methods We performed genome-wide association analyses within 15 subgroups of breast cancer patients based on prognostic factors, including hormone receptors, tumor grade, age, and type of systemic treatment. Analyses were based on 91,686 female patients of European ancestry from the Breast Cancer Association Consortium, including 7531 breast cancer-specific deaths over a median follow-up of 8.1 years. Cox regression was used to assess associations of common germline variants with 15-year and 5-year breast cancer-specific survival. We assessed the probability of these associations being true positives via the Bayesian false discovery probability (BFDP < 0.15). Results Evidence of associations with breast cancer-specific survival was observed in three patient subgroups, with variant rs5934618 in patients with grade 3 tumors (15-year-hazard ratio (HR) [95% confidence interval (CI)] 1.32 [1.20, 1.45], P = 1.4E-08, BFDP = 0.01, per G allele); variant rs4679741 in patients with ER-positive tumors treated with endocrine therapy (15-year-HR [95% CI] 1.18 [1.11, 1.26], P = 1.6E-07, BFDP = 0.09, per G allele); variants rs1106333 (15-year-HR [95% CI] 1.68 [1.39,2.03], P = 5.6E-08, BFDP = 0.12, per A allele) and rs78754389 (5-year-HR [95% CI] 1.79 [1.46,2.20], P = 1.7E-08, BFDP = 0.07, per A allele), in patients with ER-negative tumors treated with chemotherapy. Conclusions We found evidence of four loci associated with breast cancer-specific survival within three patient subgroups. There was limited evidence for the existence of associations in other patient subgroups. However, the power for many subgroups is limited due to the low number of events. Even so, our results suggest that the impact of common germline genetic variants on breast cancer-specific survival might be limited.

Titel:	Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment
Autor/in / Beteiligte Person:	Morra, Anna ; Escala-Garcia, Maria ; Beesley, Jonathan ; Keeman, Renske ; Canisius, Sander ; Ahearn, Thomas U. ; Andrulis, Irene L. ; Anton-Culver, Hoda ; Arndt, Volker ; Auer, Paul L. ; Augustinsson, Annelie ; Freeman, Laura E. Beane ; Becher, Heiko ; Beckmann, Matthias W. ; Behrens, Sabine ; Bojesen, Stig E. ; Bolla, Manjeet K. ; Brenner, Hermann ; Bruening, Thomas ; Buys, Saundra S. ; Caan, Bette ; Campa, Daniele ; Canzian, Federico ; Castelao, Jose E. ; Chang-Claude, Jenny ; Chanock, Stephen J. ; Cheng, Ting-Yuan David ; Clarke, Christine L. ; Colonna, Sarah, V ; Couch, Fergus J. ; Cox, Angela ; Cross, Simon S. ; Czene, Kamila ; Daly, Mary B. ; Dennis, Joe ; Dork, Thilo ; Dossus, Laure ; Dunning, Alison M. ; Dwek, Miriam ; Eccles, Diana M. ; Ekici, Arif B. ; Eliassen, A. Heather ; Eriksson, Mikael ; Evans, D. Gareth ; Fasching, Peter A. ; Flyger, Henrik ; Fritschi, Lin ; Gago-Dominguez, Manuela ; Garcia-Saenz, Jose A. ; Giles, Graham G. ; Grip, Mervi ; Guenel, Pascal ; Guendert, Melanie ; Hahnen, Eric ; Haiman, Christopher A. ; Hakansson, Niclas ; Hall, Per ; Hamann, Ute ; Hart, Steven N. ; Hartikainen, Jaana M. ; Hartmann, Arndt ; He, Wei ; Hooning, Maartje J. ; Hoppe, Reiner ; Hopper, John L. ; Howell, Anthony ; Hunter, David J. ; Jager, Agnes ; Jakubowska, Anna ; Janni, Wolfgang ; John, Esther M. ; Jung, Audrey Y. ; Kaaks, Rudolf ; Keupers, Machteld ; Kitahara, Cari M. ; Koutros, Stella ; Kraft, Peter ; Kristensen, Vessela N. ; Kurian, Allison W. ; Lacey, James, V ; Lambrechts, Diether ; Le Marchand, Loic ; Lindblom, Annika ; Linet, Martha ; Luben, Robert N. ; Lush, Michael ; Mannermaa, Arto ; Manoochehri, Mehdi ; Margolin, Sara ; Martens, John W. M. ; Martinez, Maria Elena ; Mavroudis, Dimitrios ; Michailidou, Kyriaki ; Milne, Roger L. ; Mulligan, Anna Marie ; Muranen, Taru A. ; Nevanlinna, Heli ; Newman, William G. ; Nielsen, Sune F. ; Nordestgaard, Borge G. ; Olshan, Andrew F. ; Olsson, Hakan ; Orr, Nick ; Park-Simon, Tjoung-Won ; Patel, Alpa, V ; Peissel, Bernard ; Peterlongo, Paolo ; Plaseska-Karanfilska, Dijana ; Prajzendanc, Karolina ; Prentice, Ross ; Presneau, Nadege ; Rack, Brigitte ; Rennert, Gad ; Rennert, Hedy S. ; Rhenius, Valerie ; Romero, Atocha ; Roylance, Rebecca ; Lubinski, Jan ; Ruebner, Matthias ; Saloustros, Emmanouil ; Sawyer, Elinor J. ; Schmutzler, Rita K. ; Schneeweiss, Andreas ; Scott, Christopher ; Shah, Mitul ; Smichkoska, Snezhana ; Southey, Melissa C. ; Stone, Jennifer ; Surowy, Harald ; Swerdlow, Anthony J. ; Tamimi, Rulla M. ; Tapper, William J. ; Teras, Lauren R. ; Terry, Mary Beth ; Tollenaar, Rob A. E. M. ; Tomlinson, Ian ; Troester, Melissa A. ; Truong, Therese ; Vachon, Celine M. ; Wang, Qin ; Hurson, Amber N. ; Winqvist, Robert ; Wolk, Alicja ; Ziogas, Argyrios ; Brauch, Hiltrud ; Garcia-Closas, Montserrat ; Pharoah, Paul D. P. ; Easton, Douglas F. ; Chenevix-Trench, Georgia ; Schmidt, Marjanka K.
Link:	Volltext https://doi.org/10.1186/s13058-021-01450-7
Veröffentlichung:	Uppsala universitet, Medicinsk epidemiologi ; Antoni van Leeuwenhoek Hosp, Div Mol Pathol, Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands. ; QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia. ; Antoni van Leeuwenhoek Hosp, Div Mol Pathol, Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands.;Antoni van Leeuwenhoek Hosp, Div Mol Carcinogenesis, Netherlands Canc Inst, Amsterdam, Netherlands. ; NCI, US Dept HHS, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. ; Fred A Litwin Ctr Canc Genet, Lunenfeld Tanenbaum Res Inst Mt Sinai Hosp, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada. ; Univ Calif Irvine, Dept Med, Genet Epidemiol Res Inst, Irvine, CA 92717 USA. ; German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany. ; Fred Hutchinson Canc Res Ctr, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Wisconsin, Zilber Sch Publ Hlth, Milwaukee, WI 53201 USA. ; Lund Univ, Dept Canc Epidemiol, Clin Sci, Lund, Sweden. ; Univ Med Ctr Hamburg Eppendorf, Inst Med Biometry & Epidemiol, Hamburg, Germany. ; Friedrich Alexander Univ Erlangen Nuremberg FAU, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Dept Gynecol & Obstet, Erlangen, Germany. ; German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany. ; Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark. ; Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England. ; German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.;Natl Ctr Tumor Dis NCT, Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany. ; Inst Ruhr Univ Bochum IPA, Inst Prevent & Occupat Med, German Social Accid Insurance, Bochum, Germany. ; Huntsman Canc Inst, Dept Med, Salt Lake City, UT USA. ; Kaiser Permanente, Div Res, Oakland, CA USA. ; German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Univ Pisa, Dept Biol, Pisa, Italy. ; German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany. ; Xerencia Xest Integrada Vigo SERGAS, Oncol & Genet Unit, Inst Invest Sanitaria Galicia Sur IISGS, Vigo, Spain. ; German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Univ Med Ctr Hamburg Eppendorf, Univ Canc Ctr Hamburg UCCH, Canc Epidemiol Grp, Hamburg, Germany. ; Roswell Park Canc Inst, Div Canc Prevent & Control, Buffalo, NY 14263 USA. ; Univ Sydney, Westmead Inst Med Res, Sydney, NSW, Australia. Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, Radiumhosp, Oslo, Norway. ; Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA. ; Univ Sheffield, Sheffield Inst Nucle Acids SInFoNiA, Dept Oncol & Metab, Sheffield, S Yorkshire, England. ; Univ Sheffield, Acad Unit Pathol, Dept Neurosci, Sheffield, S Yorkshire, England. ; Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. ; Fox Chase Canc Ctr, Dept Clin Genet, 7701 Burholme Ave, Philadelphia, PA 19111 USA. ; Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany. ; Int Agcy Res Canc IARC WHO, Nutr & Metab Sect, Lyon, France. ; Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England. ; Univ Westminster, Sch Life Sci, London, England. ; Univ Southampton, Fac Med, Southampton, Hants, England. ; Friedrich Alexander Univ Erlangen Nuremberg FAU, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Inst Human Genet, Erlangen, Germany. ; Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Channing Div Network Med, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA. ; Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Sch Biol Sci,Div Evolut & Genom Sci, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, St Marys Hosp, Manchester Acad Hlth Sci Ctr, North West Genom Lab Hub,Manchester Ctr Genom Med, Manchester, Lancs, England. ; Friedrich Alexander Univ Erlangen Nuremberg FAU, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Dept Gynecol & Obstet, Erlangen, Germany.;Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Hematol & Oncol, Los Angeles, CA 90095 USA. ; Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Breast Surg, Herlev, Denmark. ; Curtin Univ, Sch Publ Hlth, Perth, WA, Australia. ; Galician Publ Fdn Genom Med FPGMX, Hlth Res Inst Santiago IDIS, Int Canc Genet & Epidemiol Grp, Genom Med Grp, Santiago De Compostela, Spain.;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA. ; Hosp Clin San Carlos, Ctr Invest Biomed Red Canc CIBERONC, Inst Invest Sanitaria San Carlos IdISSC, Med Oncol Dept, Madrid, Spain. ; Canc Council Victoria, Canc Epidemiol Div, Victoria, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Victoria, Australia.;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia. ; Univ Oulu, Oulu Univ Hosp, Dept Surg, Oulu, Finland. ; Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP, INSERM, Team Exposome & Hered, Villejuif, France. ; German Canc Res Ctr, Mol Epidemiol Grp, C080, Heidelberg, Germany.;Heidelberg Univ, Univ Womens Clin Heidelberg, Mol Biol Breast Canc, Heidelberg, Germany.;Helmholtz Zentrum Munchen, Inst Diabet Res, German Res Ctr Environm Hlth, Neuherberg, Germany. ; Univ Cologne, Fac Med, Cologne, Germany.;Univ Cologne, Univ Hosp Cologne, Ctr Integrated Oncol CIO, Cologne, Germany. ; Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA. ; Karolinska Inst, Inst Environm Med, Stockholm, Sweden. ; Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Soder Sjukhuset, Dept Oncol, Stockholm, Sweden. ; German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany. ; Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA. ; Univ Eastern Finland, Translat Canc Res Area, Kuopio, Finland.;Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, Kuopio, Finland. ; Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen Nuremberg, Inst Pathol, Erlangen, Germany. ; Erasmus MC Canc Inst, Dept Med Oncol, Rotterdam, Netherlands. ; Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany.;Univ Tubingen, Tubingen, Germany. ; Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Victoria, Australia. ; Univ Manchester, Div Canc Sci, Manchester, Lancs, England. ; Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England. ; Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland.;Pomeranian Med Univ, Independent Lab Mol Biol & Genet Diagnost, Szczecin, Poland. ; Univ Hosp Ulm, Dept Gynaecol & Obstet, Ulm, Germany. ; Stanford Univ, Dept Epidemiol & Populat Hlth, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Canc Inst, Dept Med, Div Oncol,Sch Med, Stanford, CA 94305 USA. ; Univ Leuven, Univ Hosp Leuven, Dept Radiat Oncol, Leuven, Belgium. ; NCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD 20892 USA. ; Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA. ; Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway. Vestre Viken Hosp, Dept Res, Drammen, Norway. Oslo Univ Hosp Ulleval, Dept Canc, Div Surg Canc & Transplantat Med, Sect Breast & Endocrine Surg, Oslo, Norway. Oslo Univ Hosp, Dept Radiol & Nucl Med, Oslo, Norway. Akershus Univ Hosp, Dept Pathol, Lorenskog, Norway. Oslo Univ Hosp, Inst Canc Res, Dept Tumor Biol, Oslo, Norway. Oslo Univ Hosp, Dept Oncol, Div Surg Canc & Transplantat Med, Radiumhosp, Oslo, Norway. Oslo Univ Hosp, Natl Advisory Unit Late Effects Canc Treatment, Radiumhosp, Oslo, Norway. Akershus Univ Hosp, Dept Oncol, Lorenskog, Norway. Oslo Univ Hosp, Breast Canc Res Consortium, Oslo, Norway.;Oslo Univ Hosp, Dept Med Genet, Oslo, Norway.;Univ Oslo, Oslo, Norway. ; City Hope Natl Med Ctr, Dept Computat & Quantitat Med, Duarte, CA USA.;City Hope Natl Med Ctr, City Hope Comprehens Canc Ctr, Duarte, CA USA. ; VIB Ctr Canc Biol, Leuven, Belgium.;Univ Leuven, Dept Human Genet, Lab Translat Genet, Leuven, Belgium. ; Univ Hawaii, Canc Ctr, Epidemiol Program, Honolulu, HI 96822 USA. ; Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden. ; Univ Cambridge, Dept Publ Hlth & Primary Care, Clin Gerontol, Cambridge, England. ; Univ Eastern Finland, Translat Canc Res Area, Kuopio, Finland.;Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, Kuopio, Finland.;Kuopio Univ Hosp, Biobank Eastern Finland, Kuopio, Finland. ; Soder Sjukhuset, Dept Oncol, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden. ; Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA. ; Univ Hosp Heraklion, Dept Med Oncol, Iraklion, Greece. ; Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.;Cyprus Inst Neurol & Genet, Biostat Unit, Nicosia, Cyprus.;Cyprus Sch Mol Med, Cyprus Inst Neurol & Genet, Nicosia, Cyprus. ; Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.;Univ Hlth Network, Lab Med Program, Toronto, ON, Canada. ; Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Helsinki, Finland. ; Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark. ; Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.;Univ N Carolina, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA. ; Queens Univ Belfast, Ctr Canc Res & Cell Biol, Belfast, Antrim, North Ireland. ; Amer Canc Soc, Dept Populat Sci, Atlanta, GA 30329 USA. ; Fdn IRCCS Ist Nazl Tumori Milano, Dept Med Oncol & Hematol, Unit Med Genet, Milan, Italy. ; IFOM FIRC Inst Mol Oncol, Genome Diagnost Program, Milan, Italy. ; Res Ctr Genet Engn & Biotechnol Georgi D Efremov, MASA, Skopje, North Macedonia. ; Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland. ; Fred Hutchinson Canc Res Ctr, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA. ; Carmel Hosp, Haifa, Israel.;Technion Fac Med, Clalit Natl Canc Control Ctr, Haifa, Israel. ; Hosp Univ Puerta de Hierro, Med Oncol Dept, Madrid, Spain. ; UCLH Fdn Trust, Dept Oncol, London, England. ; Univ Hosp Larissa, Dept Oncol, Larisa, Greece. ; Kings Coll London, Comprehens Canc Ctr, Sch Canc & Pharmaceut Sci, Guys Campus, London, England. ; Univ Cologne, Fac Med, Cologne, Germany.;Univ Cologne, Univ Hosp Cologne, Ctr Integrated Oncol CIO, Cologne, Germany.;Univ Cologne, Fac Med, Ctr Mol Med Cologne CMMC, Cologne, Germany.;Univ Cologne, Univ Hosp Cologne, Ctr Mol Med Cologne CMMC, Cologne, Germany. ; Heidelberg Univ, Univ Womens Clin Heidelberg, Mol Biol Breast Canc, Heidelberg, Germany.;Univ Hosp, Heidelberg, Germany.;German Canc Res Ctr, Natl Ctr Tumor Dis, Heidelberg, Germany. ; Ss Cyril & Methodius Univ Skopje, Univ Clin Radiotherapy & Oncol, Med Fac, Skopje, North Macedonia. ; Canc Council Victoria, Canc Epidemiol Div, Victoria, Australia.;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia.;Univ Melbourne, Dept Clin Pathol, Melbourne, Vic, Australia. ; Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Victoria, Australia.;Univ Western Australia, Sch Populat & Global Hlth, Genet Epidemiol Grp, Perth, WA, Australia. ; German Canc Res Ctr, Mol Epidemiol Grp, C080, Heidelberg, Germany.;Heidelberg Univ, Univ Womens Clin Heidelberg, Mol Biol Breast Canc, Heidelberg, Germany. ; Inst Canc Res, Div Genet & Epidemiol, London, England.;Inst Canc Res, Div Breast Canc Res, London, England. ; Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Weill Cornell Med, Dept Populat Hlth Sci, New York, NY USA. ; Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA. ; Leiden Univ Med Ctr, Dept Surg, Leiden, Netherlands. ; Univ Birmingham, Inst Canc & Genom Sci, Birmingham, W Midlands, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford NIHR Biomed Res Ctr, Oxford, England. ; Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA. ; Univ Oulu, Bioctr Oulu, Canc & Translat Med Res Unit, Lab Canc Genet & Tumor Biol, Oulu, Finland.;Northern Finland Lab Ctr Oulu, Lab Canc Genet & Tumor Biol, Oulu, Finland. ; Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany.;Univ Tubingen, iFIT Cluster Excellence, Tubingen, Germany.;German Canc Res Ctr, Tubingen, Germany.;German Canc Consortium DKTK, Partner Site Tubingen, Tubingen, Germany. ; Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England. ; Antoni van Leeuwenhoek Hosp, Div Mol Pathol, Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands.;Antoni van Leeuwenhoek Hosp, Div Psychosocial Res & Epidemiol, Netherlands Canc Inst, Amsterdam, Netherlands. ; BMC, 2021
Medientyp:	academicJournal
DOI:	10.1186/s13058-021-01450-7
Schlagwort:	Common germline genetic variants Breast cancer-specific survival Patient subgroups Tumor biology Systemic treatment Cancer and Oncology Cancer och onkologi
Sonstiges:	Nachgewiesen in: BASE Sprachen: English Collection: Uppsala University: Publications (DiVA) Document Type: article in journal/newspaper File Description: application/pdf Language: English Rights: info:eu-repo/semantics/openAccess

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