6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice ...
ETH Zurich, 2023
Online
academicJournal
Zugriff:
Objective Dietary fibres are essential for maintaining microbial diversity and the gut microbiota can modulate host physiology by metabolising the fibres. Here, we investigated whether the soluble dietary fibre oligofructose improves host metabolism by modulating bacterial transformation of secondary bile acids in mice fed western-style diet. Design To assess the impact of dietary fibre supplementation on bile acid transformation by gut bacteria, we fed conventional wild-type and TGR5 knockout mice western-style diet enriched or not with cellulose or oligofructose. In addition, we used germ-free mice and in vitro cultures to evaluate the activity of bacteria to transform bile acids in the caecal content of mice fed with western-style diet enriched with oligofructose. Finally, we treated wild-type and TGR5 knockout mice orally with hyodeoxycholic acid to assess its antidiabetic effects. Results We show that oligofructose sustains the production of 6α-hydroxylated bile acids from primary bile acids by gut ... : Gut, 72 (2) ...
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6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice ...
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Autor/in / Beteiligte Person: | Makki, Kassem ; Brolin, Harald ; Petersen, Natalia ; Henricsson, Marcus ; Christensen, Dan Ploug ; Khan, Muhammad Tanweer ; Wahlström, Annika ; Bergh, Per-Olof ; Tremaroli, Valentina ; Schoonjans, Kristina ; Marschall, Hanns-Ulrich ; Bäckhed, Fredrik |
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Veröffentlichung: | ETH Zurich, 2023 |
Medientyp: | academicJournal |
DOI: | 10.3929/ethz-b-000553802 |
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