Effective inhibition of the early copper ion burst release with ultra-fine grained copper and single crystal copper for intrauterine device application
In: SCI, 2012
Online
academicJournal
To solve the main problems of existing coarse grained copper (CG Cu) intrauterine devices (IUD)-namely burst release and a low transfer efficiency of the cupric ions during usage-ultra-fine grained copper (UFG Cu) and single crystal copper (SC Cu) have been investigated as potential substitutes. Their corrosion properties with CG Cu as a control have been studied in simulated uterine fluid (SUF) under different conditions using electrochemical measurement methods. Long-term immersion of UFG Cu, SC Cu and CG Cu samples in SUF at 37 degrees C have been studied for 300 days. A lower copper ion burst release and a higher efficiency release of cupric ions were observed for UFG Cu and SC Cu compared with CG Cu in the first month of immersion and 2 months later. The respective corrosion mechanisms for UFG Cu, SC Cu and CG Cu in SUF are proposed. In vitro biocompatibility tests show a better cellular response to UFG Cu and SC Cu than CG Cu. In terms of instantaneous corrosion behavior, long-term corrosion performance and in vitro biocompatibility, the three pure copper materials follow the order: UFG Cu > SC Cu > CG Cu, which indicates that UFG Cu could be the most suitable candidate material for intrauterine devices. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. ; Engineering, Biomedical ; Materials Science, Biomaterials ; SCI(E) ; 8 ; ARTICLE ; 2 ; 886-896 ; 8
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Effective inhibition of the early copper ion burst release with ultra-fine grained copper and single crystal copper for intrauterine device application
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Autor/in / Beteiligte Person: | Xu, X. X. ; Nie, F. L. ; Wang, Y. B. ; Zhang, J. X. ; Zheng, W. ; Li, L. ; Zheng, Y. F. ; Zheng, YF (reprint author), Peking Univ, Dept Mat Sci & Engn, Coll Engn, Beijing 100871, Peoples R China. ; Peking Univ, Dept Mat Sci & Engn, Coll Engn, Beijing 100871, Peoples R China. ; Harbin Engn Univ, Ctr Biomed Mat & Engn, Harbin 150001, Peoples R China. |
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Zeitschrift: | SCI, 2012 |
Veröffentlichung: | acta biomaterialia, 2012 |
Medientyp: | academicJournal |
ISSN: | 1742-7061 (print) |
DOI: | 10.1016/j.actbio.2011.10.018 |
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