Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins, and prostate cancer risk: a prospective study.
In: JNCI: Journal of the National Cancer Institute, Jg. 92 (2000-12-06), Heft 23, S. 1910-1917
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Zugriff:
Background: Recent studies have suggested that men with elevated plasma levels of insulin-like growth factor-I (IGF-I) may have an increased risk of prostate cancer. Furthermore, IGF-binding proteins (IGFBPs) and insulin can modulate the activity of IGF-I. In this study, we sought to determine the role of IGF-I as well as IGFBPs-1, -2, and -3 and insulin as possible etiologic factors for prostate cancer. Methods: We conducted a nested case-control study within the Northern Sweden Health and Disease Cohort Study. We measured levels of IGF-I, IGFBP-1, IGFBP-2, IGFBP-3, and insulin in plasma samples from 149 men who had a diagnosis of prostate cancer between 1 month and 10 years after blood collection and among 298 control men. All statistical tests are two-sided. Results: Case subjects had statistically significantly higher mean levels of IGF-I than control subjects (229 ng/mL; 95% confidence interval [CI] = 218-240 ng/mL] versus 214 ng/mL [95% CI = 208-221 ng/mL]; P =.02) and IGFBP-3 (2611 ng/mL [95% CI = 2518-2704 ng/mL] versus 2498 ng/mL [95% CI = 2437-2560 ng/mL]; P =.04). Conditional logistic regression analyses showed increases in prostate cancer risk with rising levels of IGF-I (P:(for trend) =.02) and IGFBP-3 (P(for trend) =.03). In case subjects younger than 59 years at the time of blood collection, the risk associated with increased IGF-I was higher (P:(for trend) =.01), whereas the risk associated with increased IGFBP-3 was lower (P(for trend) =.44) than the corresponding risks in the full cohort. Prostate cancer risk was not associated with levels of IGFBP-1, IGFBP-2, or insulin. Conclusions: Prostate cancer risk is increased in men with elevated plasma IGF-I. This association was particularly strong in younger men in this study, suggesting that circulating IGF-I may be specifically involved in the early pathogenesis of prostate cancer. [ABSTRACT FROM AUTHOR]
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Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins, and prostate cancer risk: a prospective study.
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Autor/in / Beteiligte Person: | Stattin, Par ; Bylund, Annika ; Rinaldi, Sabina ; Biessy, Carine ; Dechaud, Henri ; Stenman, Ulf-Hakan ; Egevad, Lars ; Riboli, Elio ; Hallmans, Goran ; Kaaks, Rudolf ; Stattin, P ; Bylund, A ; Rinaldi, S ; Biessy, C ; Déchaud, H ; Stenman, U H ; Egevad, L ; Riboli, E ; Hallmans, G ; Kaaks, R |
Zeitschrift: | JNCI: Journal of the National Cancer Institute, Jg. 92 (2000-12-06), Heft 23, S. 1910-1917 |
Veröffentlichung: | 2000 |
Medientyp: | academicJournal |
ISSN: | 0027-8874 (print) |
DOI: | 10.1093/jnci/92.23.1910 |
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