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Extracellular vesicles as potential biomarkers for diagnosis and recurrence detection of hepatocellular carcinoma.
In: Scientific Reports, Jg. 14 (2024-03-04), Heft 1, S. 1-8
Online
academicJournal
Zugriff:
Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor and a leading cause of cancer-related deaths worldwide. However, current diagnostic tools are often invasive and technically limited. In the last decade, non-invasive liquid biopsies have transformed the field of clinical oncology, showcasing the potential of various liquid-biopsy derived analytes, including extracellular vesicles (EVs), to diagnose and monitor HCC progression and metastatic spreading, serving as promising novel biomarkers. A prospective single-center cohort study including 37 HCC patients and 20 patients with non-malignant liver disease (NMLD), as a control group, was conducted. Serum EVs of both groups were analyzed before and after liver surgery. The study utilized microbead-based magnetic particle sorting and flow cytometry to detect 37 characteristic surface proteins of EVs. Furthermore, HCC patients who experienced tumor recurrence (R-HCC) within 12 months after surgery were compared to HCC patients without recurrence (NR-HCC). EVs of R-HCC patients (n = 12/20) showed significantly lower levels of CD31 compared to EVs of NR-HCC patients (p = 0.0033). EVs of NMLD-group showed significantly higher expressions of CD41b than EVs of HCC group (p = 0.0286). The study determined significant short-term changes in CD19 dynamics in EVs of the NMLD-group, with preoperative values being significantly higher than postoperative values (p = 0.0065). This finding of our pilot study suggests EVs could play a role as potential targets for the development of diagnostic and therapeutic approaches for the early and non-invasive detection of HCC recurrence. Further, more in-depth analysis of the specific EV markers are needed to corroborate their potential role as diagnostic and therapeutic targets for HCC. [ABSTRACT FROM AUTHOR]
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Titel: |
Extracellular vesicles as potential biomarkers for diagnosis and recurrence detection of hepatocellular carcinoma.
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Autor/in / Beteiligte Person: | Juratli, Mazen A. ; Pollmann, Nicola S. ; Oppermann, Elsie ; Mohr, Annika ; Roy, Dhruvajyoti ; Schnitzbauer, Andreas ; Michalik, Sabine ; Vogl, Thomas ; Stoecklein, Nikolas H. ; Houben, Philipp ; Katou, Shadi ; Becker, Felix ; Hoelzen, Jens Peter ; Andreou, Andreas ; Pascher, Andreas ; Bechstein, Wolf O. ; Struecker, Benjamin |
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Zeitschrift: | Scientific Reports, Jg. 14 (2024-03-04), Heft 1, S. 1-8 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 2045-2322 (print) |
DOI: | 10.1038/s41598-024-55888-8 |
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