Cortical Amyloid Burden Relates to Basal Forebrain Volume in Subjective Cognitive Decline.
In: Journal of Alzheimer's Disease, Jg. 95 (2023-10-01), Heft 3, S. 1013-1028
academicJournal
Zugriff:
Background: Atrophy of cholinergic basal forebrain (BF) nuclei is a frequent finding in magnetic resonance imaging (MRI) volumetry studies that examined patients with prodromal or clinical Alzheimer's disease (AD), but less clear for individuals in earlier stages of the clinical AD continuum. Objective: To examine BF volume reductions in subjective cognitive decline (SCD) participants with AD pathologic changes. Methods: The present study compared MRI-based BF volume measurements in age- and sex-matched samples of N = 24 amyloid-positive and N = 24 amyloid-negative SCD individuals, based on binary visual ratings of Florbetaben positron emission tomography (PET) measurements. Additionally, we assessed associations of BF volume with cortical amyloid burden, based on semiquantitative Centiloid (CL) analyses. Results: Group differences approached significance for BF total volume (p = 0.061) and the Ch4 subregion (p = 0.059) only, showing the expected relative volume reductions for the amyloid-positive subgroup. There were also significant inverse correlations between BF volumes and CL values, which again were most robust for BF total volume and the Ch4 subregion. Conclusions: The results are consistent with the hypothesis that amyloid-positive SCD individuals, which are considered to represent a transitional stage on the clinical AD continuum, already show incipient alterations of BF integrity. The negative association with a continuous measure of cortical amyloid burden also suggests that this may reflect an incremental process. Yet, further research is needed to evaluate whether BF changes already emerge at "grey zone" levels of amyloid accumulation, before amyloidosis is reliably detected by PET visual readings. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Alzheimer's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Cortical Amyloid Burden Relates to Basal Forebrain Volume in Subjective Cognitive Decline.
|
---|---|
Autor/in / Beteiligte Person: | Daamen, Marcel ; Scheef, Lukas ; Li, Shumei ; Grothe, Michel J. ; Gaertner, Florian C. ; Buchert, Ralph ; Buerger, Katharina ; Dobisch, Laura ; Drzezga, Alexander ; Essler, Markus ; Ewers, Michael ; Fliessbach, Klaus ; Herrera Melendez, Ana Lucia ; Hetzer, Stefan ; Janowitz, Daniel ; Kilimann, Ingo ; Krause, Bernd Joachim ; Lange, Catharina ; Laske, Christoph ; Munk, Matthias H. |
Zeitschrift: | Journal of Alzheimer's Disease, Jg. 95 (2023-10-01), Heft 3, S. 1013-1028 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1387-2877 (print) |
DOI: | 10.3233/JAD-230141 |
Schlagwort: |
|
Sonstiges: |
|